Didemnacerides A 和 B：两种来自红海海鞘 Didemnum 物种的新甘油酯。

Didemnacerides A and B: two new glycerides from Red Sea ascidian Didemnum species.

机构信息

a Department of Pharmacognosy and Medicinal Chemistry , Faculty of Pharmacy, Taibah University , Al Madinah Al Munawwarah 41477 , Saudi Arabia.

出版信息

Nat Prod Res. 2014;28(19):1591-7. doi: 10.1080/14786419.2014.927874. Epub 2014 Jun 18.

DOI:10.1080/14786419.2014.927874

PMID:24938879

Abstract

Two new glycerides, didemnacerides A (1) and B (2), together with three known sterols, 24-ethyl-25-hydroxycholesterol (3), cholest-6-en-3,5,8-triol (4) and cholestane-3β,5α,6β-26-tetrol (5), were isolated from the Red Sea ascidian Didemnum sp. Their structures were elucidated by using extensive 1D ((1)H, (13)C) and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR studies and mass spectroscopic data (GC-MS and HR-MS) as well as alkaline hydrolysis followed by GC-MS and NMR spectral analyses of the fatty acid methyl esters. This is the first report of compounds 3-5 from the Red Sea ascidian Didemnum species.

摘要

两种新的甘油酯，didemnacerides A（1）和 B（2），以及三种已知的甾醇，24-乙基-25-羟基胆固醇（3）、胆甾-6-烯-3,5,8-三醇（4）和胆甾烷-3β,5α,6β-26-四醇（5），从红海海鞘 Didemnum sp. 中分离得到。通过广泛的 1D((1)H, (13)C)和 2D((1)H-(1)H COSY、HSQC 和 HMBC)NMR 研究以及质谱数据（GC-MS 和 HR-MS）以及碱水解，随后对脂肪酸甲酯进行 GC-MS 和 NMR 光谱分析，确定了它们的结构。这是首次从红海海鞘 Didemnum 属中分离得到化合物 3-5。