Nankar Meenakshi, Walimbe Hrishikesh, Ahmed Bijle Mohammed Nadeem, Kontham Ujwal, Kamath Ananth, Muchandi Sneha
Postgraduate Student, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
Reader, Department of Pedodontics and Preventive Dentistry Dr DY Patil Vidyapeeth, Dr DY Patil Dental College and Hospital Pimpri, Pune, Maharashtra, India.
J Contemp Dent Pract. 2014 Jan 1;15(1):20-5. doi: 10.5005/jp-journals-10024-1481.
Liquid oral medicines being the most accepted form of medication in children are frequently prescribed. The harmful effects of these liquid medicaments on a child's dental health are not known to many. The present study aimed to evaluate and compare the cariogenic and erosive potential of 5 most commonly prescribed pediatric liquid medicaments (PLM) in Pimpri Chinchwad and Pune city, Pune district.
Most commonly prescribed PLM in Pune district were selected as opined by 50 pediatricians. The selected medicaments were Syr. Augmentin® Duo, Syr. Valparin®, Syr. Combiflam®, Syr. Visyneral and Syr. Orofer®. An estimation of pH, percentage of sucrose concentration and calcium dissolving capacity of these preparations was carried out. The results as obtained were subjected to statistical analysis using SPSS v 17.0 for windows. The statistical test as undertaken was Pearson's correlation coeffcient(r).
Sucrose was seen to be present in Syr. Combiflam® (35.75% ± 0.25%) and Syr. Visyneral (18.48% ± 0.43%). Acidic pH was observed for Syr. Visyneral (mean pH 3.63 ± 0.04), Syr. Combiflam®(mean pH 5.03 ± 0.02) and Syr. Augmentin® (mean pH 6.22 ± 0.02). Highest calcium dissolution was seen with Syr. Combiflam®(295.86 mg/ml) and the least with Syr. Orofer® (25.51 mg/ml). No statistical significant correlation was observed with calcium dissolution potential of PLM in comparison with their respective pH.
Syr. Combiflam® can be regarded as the highest cariogenic and erosive potential medicament among the compared and tested PLM.
Considering syrups with high cariogenic and erosive potential should always follow with proper oral hygiene practices or search for an alternative drugs void of such detrimental effects.
液体口服药物是儿童最常接受的药物剂型，经常被开出处方。许多人并不了解这些液体药物对儿童牙齿健康的有害影响。本研究旨在评估和比较浦那地区皮姆普里钦奇瓦德和浦那市5种最常用的儿科液体药物（PLM）的致龋和侵蚀潜力。
根据50位儿科医生的意见，选择了浦那地区最常用的PLM。所选药物为阿莫西林克拉维酸钾干混悬剂（Syr. Augmentin® Duo）、丙戊酸钠糖浆（Syr. Valparin®）、复方锌铁钙口服溶液（Syr. Combiflam®）、多种维生素糖浆（Syr. Visyneral）和蛋白琥珀酸铁口服溶液（Syr. Orofer®）。对这些制剂的pH值、蔗糖浓度百分比和钙溶解能力进行了测定。所得结果使用SPSS v 17.0 for windows进行统计分析。所采用的统计检验是皮尔逊相关系数（r）。
在复方锌铁钙口服溶液（35.75% ± 0.25%）和多种维生素糖浆（18.48% ± 0.43%）中发现含有蔗糖。多种维生素糖浆（平均pH 3.63 ± 0.04）、复方锌铁钙口服溶液（平均pH 5.03 ± 0.02）和阿莫西林克拉维酸钾干混悬剂（平均pH 6.22 ± 0.02）的pH值呈酸性。复方锌铁钙口服溶液的钙溶解量最高（295.86毫克/毫升），蛋白琥珀酸铁口服溶液的钙溶解量最低（25.
