Curmi P A, Tedgui A
Institut national de la Santé et de la Recherche médicale, Unité 141, Hôpital Lariboisière, Paris.
C R Acad Sci III. 1989;308(6):149-54.
In an attempt to investigate the effects of transmural pressure on LDL transport and distribution across the arterial wall, uptake of labeled LDL has been measured in excised rabbit thoracic aorta, held at in vivo length and pressurized to 70 or 160 mmHg. The transmural distribution of LDL concentration across the wall was determined by examining serial frozen sections cut parallel to the luminal surface at 20 microns intervals from the intima to adventitia. The LDL concentration observed in the first luminal section at 160 mmHg was 20-fold higher than that obtained at 70 mmHg. The LDL concentrations decreased in the subsequent sections of the first half of the media and became similar, in the outer half of the media, to the values observed under normal pressure. These results might provide an account of one of the mechanisms involved in the deleterious effects of hypertension in atherogenesis.
为了研究跨壁压力对低密度脂蛋白（LDL）在动脉壁内转运和分布的影响，在保持体内长度并加压至70或160 mmHg的离体兔胸主动脉中测量了标记LDL的摄取。通过检查从内膜到外膜以20微米间隔平行于管腔表面切割的连续冰冻切片，确定LDL浓度在整个血管壁的跨壁分布。在160 mmHg时第一个管腔切片中观察到的LDL浓度比在70 mmHg时高20倍。LDL浓度在中膜前半部分的后续切片中降低，并在中膜后半部分变得与常压下观察到的值相似。这些结果可能解释了高血压在动脉粥样硬化发生中有害作用所涉及的机制之一。
