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三磷酸腺苷（ATP）通过与磷脂酶C偶联的百日咳毒素敏感鸟嘌呤核苷酸结合蛋白刺激人中性粒细胞和HL60细胞的分泌。

ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C.

作者信息

Cockcroft S, Stutchfield J

机构信息

Department of Experimental Pathology, School of Medicine, University College London, England.

出版信息

FEBS Lett. 1989 Mar 13;245(1-2):25-9. doi: 10.1016/0014-5793(89)80184-x.

DOI:10.1016/0014-5793(89)80184-x
PMID:2494077
Abstract

Human neutrophils and HL60 cells respond to extracellular ATP by causing exocytotic secretion. Secretion is accompanied by increases in inositol phosphates and a rise in cytosol Ca2+. The responses to ATP are blocked by pertussis toxin pretreatment, indicating the involvement of a guanine nucleotide regulatory protein. Other nucleotides that are active in promoting secretion are ATP gamma S, UTP, ITP and AppNHp, whilst 8-bromo-ATP, AppCH2p, ADP, AMP and adenosine are inactive.

摘要

人类嗜中性粒细胞和HL60细胞通过引起胞吐分泌对细胞外ATP作出反应。分泌伴随着肌醇磷酸的增加和胞质溶胶Ca2+的升高。对ATP的反应被百日咳毒素预处理所阻断，表明鸟嘌呤核苷酸调节蛋白参与其中。其他在促进分泌方面有活性的核苷酸是ATPγS、UTP、ITP和AppNHp，而8-溴-ATP、AppCH2p、ADP、AMP和腺苷则无活性。

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FEBS Lett. 1989 Mar 13;245(1-2):25-9. doi: 10.1016/0014-5793(89)80184-x.
2
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