State Key Laboratory of Advanced Technology for Materials Synthesis and Progressing, Wuhan University of Technology , Wuhan 430070, China.
ACS Appl Mater Interfaces. 2014 Aug 13;6(15):12931-8. doi: 10.1021/am502871t. Epub 2014 Jul 1.
Recently, we have developed a semidirect breath figure (sDBF) method for direct fabrication of large-area and ordered honeycomb structures on commercial polystyrene (PS) Petri dishes without the use of an external polymer solution. In this work, we showed that both the pore size and the pore uniformity of the breath figure patterns were controllable by solvent amount. The cross-sectional image shows that only one layer of pores was formed on the BF figure patterns. By combing the sDBF method and Pickering emulsion and using the modular building blocks, we endowed the honeycomb-structured Petri dish with molecular recognition capability via the decoration of molecularly imprinted polymer (MIP) nanoparticles into the honeycomb pores. The radioligand binding experiments show that the MIP nanoparticles on the resultant honeycomb structures maintained high molecular binding selectivity. The reusability study indicates that MIP-BF patterns had excellent mechanical stability during the radioligand binding process. We believe that the modular approach demonstrated in this work will open up further opportunities for honeycomb structure-based chemical sensors for drug analysis, substrates for catalysts, and scaffold for cell growth.
最近，我们开发了一种半直接呼吸图案（sDBF）方法，可在商业聚苯乙烯（PS）培养皿上直接制造大面积和有序的蜂窝结构，而无需使用外部聚合物溶液。在这项工作中，我们表明，通过溶剂量可以控制呼吸图案的孔径和孔径均匀性。横截面图像显示，BF 图案上仅形成了一层孔。通过结合 sDBF 方法和 Pickering 乳液并使用模块化构建块，我们通过将分子印迹聚合物（MIP）纳米颗粒装饰到蜂窝孔中来赋予具有蜂窝结构的培养皿分子识别能力。放射性配体结合实验表明，所得蜂窝结构上的 MIP 纳米颗粒保持了高分子结合选择性。可重复使用性研究表明，在放射性配体结合过程中，MIP-BF 图案具有出色的机械稳定性。我们相信，这项工作中展示的模块化方法将为基于蜂窝结构的化学传感器在药物分析、催化剂载体和细胞生长支架方面开辟更多机会。
