Noma Hidetaka, Mimura Tatsuya, Yasuda Kanako, Shimura Masahiko
Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.
Ophthalmologica. 2014;232(2):102-9. doi: 10.1159/000360303. Epub 2014 Jun 18.
Concentrations of vascular endothelial growth factor (VEGF), soluble VEGF receptor-1 (sVEGFR-1) and soluble VEGF receptor-2 (sVEGFR-2) were measured by enzyme-linked immunosorbent assay in 27 proliferative diabetic retinopathy patients who had iris neovascularization (INV) with or without neovascular glaucoma (NVG). The 27 eyes were divided into two groups, consisting of INV without elevation of the intraocular pressure (IOP; INV group) and INV with elevated IOP (NVG group). Ten patients with an idiopathic macular hole were used as the controls. The vitreous levels of VEGF, sVEGFR-1 and sVEGFR-2 showed a significant increase across the three groups. In the INV and NVG groups, the vitreous level of VEGF showed a significant correlation with the levels of sVEGFR-1 and sVEGFR-2. There was also a significant correlation between the vitreous levels of sVEGFR-1 and sVEGFR-2. These results suggest that the vitreous levels of sVEGFR-1 and sVEGFR-2 are dependent on VEGF in patients who have INV with or without NVG.
采用酶联免疫吸附测定法，对27例患有虹膜新生血管（INV）伴或不伴新生血管性青光眼（NVG）的增殖性糖尿病视网膜病变患者，检测其血管内皮生长因子（VEGF）、可溶性VEGF受体-1（sVEGFR-1）和可溶性VEGF受体-2（sVEGFR-2）的浓度。这27只眼被分为两组，即眼压未升高的INV组（INV组）和眼压升高的INV组（NVG组）。选取10例特发性黄斑裂孔患者作为对照。三组患者玻璃体中VEGF、sVEGFR-1和sVEGFR-2水平均显著升高。在INV组和NVG组中，玻璃体VEGF水平与sVEGFR-1和sVEGFR-2水平显著相关。sVEGFR-1和sVEGFR-2的玻璃体水平之间也存在显著相关性。这些结果表明，在患有或未患有NVG的INV患者中，玻璃体中sVEGFR-1和sVEGFR-2水平依赖于VEGF。
