稳定虹膜新生血管的新生血管性青光眼的水样炎症和与缺血相关的生物标志物。
Aqueous Inflammation and Ischemia-Related Biomarkers in Neovascular Glaucoma with Stable Iris Neovascularization.
机构信息
Department of Ophthalmology, China-Japan Friendship Hospital , Beijing, China.
Department of Ophthalmology, The 306th Hospital of PLA , Beijing, China.
出版信息
Curr Eye Res. 2020 Dec;45(12):1504-1513. doi: 10.1080/02713683.2020.1762226. Epub 2020 May 18.
: To characterize the aqueous levels of inflammation and ischemia-related biomarkers in a spectrum of retinal ischemic conditions, including neovascular glaucoma (NVG) with stable iris neovascularization after pan retinal photocoagulation (PRP) and anti-VEGF treatment. : Aqueous samples were collected from 139 eyes including NVG (n = 12), stable NVG (n = 26), CRVO (n = 11), NPDR (n = 18), PACG (n = 18), PDR (n = 25), BRVO (n = 7) and cataract (n = 22). The levels of VEGF-A, IL-8 and EPO were measured with ELISA. : Aqueous VEGF-A significantly decreased after anti-VEGF and PRP, from 983.79 ± 821.16 pg/ml in the NVG group (n = 11) to 256.50 ± 51.14 pg/ml in the stable NVG group (n = 24) ( = .015). Aqueous VEGF-A in stable NVG group (256.50 ± 51.14 pg/ml, n = 24) was significantly higher (ANOVA, < .001) than in CRVO (212.10 ± 19.84 pg/ml, n = 7, = .017), NPDR (221.18 ± 38.21 pg/ml, n = 14, = .015), BRVO (213.14 ± 48.50 pg/ml, n = 6, = .028) and cataract group (185.30 ± 34.35 pg/ml, n = 22, < .001). Aqueous IL-8 in stable NVG group (74.82 ± 10.78 pg/ml, n = 24) was significantly higher (ANOVA, < .001) than in CRVO (65.19 ± 15.34 pg/ml, n = 11, = .032) and cataract group (54.11 ± 12.28 pg/ml, n = 22, < .001). Aqueous EPO in stable NVG group (17.48 ± 3.02 pg/ml, n = 24) was significantly higher (ANOVA, < .001) than in BRVO (14.98 ± 2.57 pg/ml, n = 7, = .034) and cataract group (13.50 ± 2.65 pg/ml, n = 22, < .001). Aqueous concentrations of VEGF-A and IL-8 correlated positively with IOP (r = 0.413, < .001, r = 0.349, < .001, respectively, r = correlation coefficient). VEGF-A correlated positively with IL-8 and EPO ( < .001, = .002, respectively). IL-8 correlated positively with EPO ( < .001). : The aqueous levels of VEGF-A, IL-8 and EPO in NVG patients with stable iris neovascularization, who had received PRP and anti-VEGF, were still significantly higher than in control groups with some retinal ischemic conditions.
为了描述包括新生血管性青光眼（NVG）在内的一系列视网膜缺血性疾病的眼内炎症和缺血相关生物标志物水平，这些疾病在全视网膜光凝（PRP）和抗血管内皮生长因子（VEGF）治疗后表现为虹膜新生血管稳定。
收集了 139 只眼的水样液样本，包括 NVG（n=12）、稳定的 NVG（n=26）、视网膜中央静脉阻塞（CRVO）（n=11）、非增生性糖尿病性视网膜病变（NPDR）（n=18）、原发性开角型青光眼（PACG）（n=18）、增生性糖尿病性视网膜病变（PDR）（n=25）、视网膜分支静脉阻塞（BRVO）（n=7）和白内障（n=22）。通过 ELISA 测量水样液中 VEGF-A、IL-8 和 EPO 的水平。
抗 VEGF 和 PRP 治疗后，NVG 组（n=11）的眼内 VEGF-A 水平从 983.79±821.16pg/ml 显著下降至稳定 NVG 组（n=24）的 256.50±51.14pg/ml（=0.015）。稳定 NVG 组（256.50±51.14pg/ml，n=24）的眼内 VEGF-A 水平明显高于 CRVO 组（212.10±19.84pg/ml，n=7，=0.017）、NPDR 组（221.18±38.21pg/ml，n=14，=0.015）、BRVO 组（213.14±48.50pg/ml，n=6，=0.028）和白内障组（185.30±34.35pg/ml，n=22，<0.001）（ANOVA，<0.001）。稳定 NVG 组的眼内 IL-8 水平（74.82±10.78pg/ml，n=24）明显高于 CRVO 组（65.19±15.34pg/ml，n=11，=0.032）和白内障组（54.11±12.28pg/ml，n=22，<0.001）（ANOVA，<0.001）。稳定 NVG 组的眼内 EPO 水平（17.48±3.02pg/ml，n=24）明显高于 BRVO 组（14.98±2.57pg/ml，n=7，=0.034）和白内障组（13.50±2.65pg/ml，n=22，<0.001）（ANOVA，<0.001）。眼内 VEGF-A 和 IL-8 浓度与眼压呈正相关（r=0.413，<0.001，r=0.349，<0.001，分别为 r=相关系数）。VEGF-A 与 IL-8 和 EPO 呈正相关（<0.001，=0.002，分别为 r=相关系数）。IL-8 与 EPO 呈正相关（<0.001）。
在接受 PRP 和抗 VEGF 治疗后虹膜新生血管稳定的 NVG 患者的眼内 VEGF-A、IL-8 和 EPO 水平仍明显高于某些视网膜缺血性疾病的对照组。
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