Davy C W, Fulleylove M, Edmunds J G, Eichler D A, Rushton B, Tudor R J, Walker J M
Roche Products Limited, Welwyn Garden City, Herts, U.K.
J Appl Toxicol. 1989 Feb;9(1):33-7. doi: 10.1002/jat.2550090107.
Marmosets were given either a hepatotoxin, carbon tetrachloride, orally or an i.m. injection of a mytoxin, chlorpromazine. Although muscle damage alone caused small increases in the plasma levels of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and isocitrate dehydrogenase (ICDH), only the isoenzyme analysis of ICDH can differentiate definitely between liver and muscle damage. Only very severe muscle damage can increase the plasma concentration of this enzyme but, in this case, the elevation of plasma creatinine kinase levels helps differentiation. It is recommended that the elevation of ICDH is the most specific indicator of hepatic damage in the marmoset.
给狨猴口服肝毒素四氯化碳或肌肉注射肌毒素氯丙嗪。虽然单独的肌肉损伤仅导致血浆中乳酸脱氢酶、丙氨酸转氨酶、天冬氨酸转氨酶和异柠檬酸脱氢酶（ICDH）水平略有升高，但只有对ICDH进行同工酶分析才能明确区分肝损伤和肌肉损伤。只有非常严重的肌肉损伤才会增加这种酶的血浆浓度，但在这种情况下，血浆肌酸激酶水平的升高有助于鉴别。建议ICDH升高是狨猴肝损伤最特异的指标。
