Davy C W, Trennery P N, Edmunds J G, Altman J F, Eichler D A
Lab Anim. 1987 Jan;21(1):60-7. doi: 10.1258/002367787780740725.
An investigation of raised plasma aspartate aminotransferase (AST) in marmosets after intramuscular ketamine injection suggested a local myotoxicity. This was confirmed by a range of histopathological findings from myofibrillar striation loss to necrosis. In addition to the elevations in AST levels, creatine kinase and the lactate dehydrogenase-5 isoenzyme levels were elevated. It was further demonstrated that, although the physical properties of the injectable solution (pH, osmolality) and to a lesser extent the injection procedure itself caused slight changes in plasma enzyme levels, the ketamine was predominantly responsible for the lesion. No hepatic interactions were seen. This effect should be taken into consideration when this anaesthetic is used in the marmoset if the primary objectives of the experiment entail routine blood analyses.
一项关于肌肉注射氯胺酮后狨猴血浆天冬氨酸氨基转移酶（AST）升高的调查表明存在局部肌毒性。一系列从肌原纤维条纹丧失到坏死的组织病理学发现证实了这一点。除AST水平升高外，肌酸激酶和乳酸脱氢酶-5同工酶水平也升高。进一步证明，尽管可注射溶液的物理性质（pH值、渗透压）以及在较小程度上注射过程本身会导致血浆酶水平略有变化，但氯胺酮是造成损伤的主要原因。未观察到肝脏相互作用。如果实验的主要目标需要进行常规血液分析，那么在狨猴中使用这种麻醉剂时应考虑到这种影响。
