Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK,
Cell Mol Life Sci. 2014 Sep;71(18):3553-67. doi: 10.1007/s00018-014-1644-x. Epub 2014 Jun 19.
The Notch and Wnt pathways are two of only a handful of highly conserved signalling pathways that control cell-fate decisions during animal development (Pires-daSilva and Sommer in Nat Rev Genet 4: 39-49, 2003). These two pathways are required together to regulate many aspects of metazoan development, ranging from germ layer patterning in sea urchins (Peter and Davidson in Nature 474: 635-639, 2011) to the formation and patterning of the fly wing (Axelrod et al in Science 271:1826-1832, 1996; Micchelli et al in Development 124:1485-1495, 1997; Rulifson et al in Nature 384:72-74, 1996), the spacing of the ciliated cells in the epidermis of frog embryos (Collu et al in Development 139:4405-4415, 2012) and the maintenance and turnover of the skin, gut lining and mammary gland in mammals (Clayton et al in Nature 446:185-189, 2007; Clevers in Cell 154:274-284, 2013; Doupe et al in Dev Cell 18:317-323, 2010; Lim et al in Science 342:1226-1230, 2013; Lowell et al in Curr Biol 10:491-500, 2000; van et al in Nature 435:959-963, 2005; Yin et al in Nat Methods 11:106-112, 2013). In addition, many diseases, including several cancers, are caused by aberrant signalling through the two pathways (Bolós et al in Endocr Rev 28: 339-363, 2007; Clevers in Cell 127: 469-480, 2006). In this review, we will outline the two signalling pathways, describe the different points of interaction between them, and cover how these interactions influence development and disease.
Notch 和 Wnt 通路是仅有的少数几个高度保守的信号通路之一，它们在动物发育过程中控制着细胞命运的决定（Pires-daSilva 和 Sommer 在 Nat Rev Genet 4: 39-49, 2003）。这两个通路一起被需要来调节后生动物发育的许多方面，从海胆的胚层模式形成（Peter 和 Davidson 在 Nature 474: 635-639, 2011）到果蝇翅膀的形成和模式形成（Axelrod 等人在 Science 271:1826-1832, 1996；Micchelli 等人在 Development 124:1485-1495, 1997；Rulifson 等人在 Nature 384:72-74, 1996），青蛙胚胎表皮纤毛细胞的间隔（Collu 等人在 Development 139:4405-4415, 2012）以及哺乳动物的皮肤、肠道衬里和乳腺的维持和更新（Clayton 等人在 Nature 446:185-189, 2007；Clevers 在 Cell 154:274-284, 2013；Doupe 等人在 Dev Cell 18:317-323, 2010；Lim 等人在 Science 342:1226-1230, 2013；Lowell 等人在 Curr Biol 10:491-500, 2000；van 等人在 Nature 435:959-963, 2005；Yin 等人在 Nat Methods 11:106-112, 2013）。此外，许多疾病，包括几种癌症，都是由两条通路的异常信号引起的（Bolós 等人在 Endocr Rev 28: 339-363, 2007；Clevers 在 Cell 127: 469-480, 2006）。在这篇综述中，我们将概述这两条信号通路，描述它们之间的不同相互作用点，并涵盖这些相互作用如何影响发育和疾病。
