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腰椎管狭窄症的结局及其预测因素:一项12年的随访研究

Outcomes and their predictors in lumbar spinal stenosis: a 12-year follow-up.

作者信息

Adamova B, Vohanka S, Dusek L, Jarkovsky J, Chaloupka R, Bednarik J

机构信息

Department of Neurology, University Hospital and Masaryk University Brno, Jihlavska 20, 62500, Brno, Czech Republic,

出版信息

Eur Spine J. 2015 Feb;24(2):369-80. doi: 10.1007/s00586-014-3411-y. Epub 2014 Jun 19.

Abstract

PURPOSE

The aim of this prospective observational cohort study was to evaluate long-term outcomes in patients with mild-to-moderate lumbar spinal stenosis (LSS) and to analyse the predictors of clinical outcomes.

METHODS

A group of 53 patients were re-examined after a median period of 139 months. Evaluations were made of subjective clinical outcome, objective clinical outcome and its predictors, any correlation between subjective and objective outcome, and the development of changes in radiological and electrophysiological parameters after 12 years.

RESULTS

Satisfactory objective and subjective clinical outcomes were recorded in 54.7 and 43.4% of patients, respectively. No statistically significant correlation between objective and subjective clinical outcome was found (Spearman coefficient = 0.225, p = 0.132). Patients with isolated unsatisfactory subjective outcome exhibited the highest Functional Comorbidity Index of all subgroups. Electrophysiological and radiological findings did not demonstrate statistically significant changes after 12-year follow-up. Multivariate logistic regression confirmed only the lowest transverse diameter of spinal canal ≦13.6 mm as an independent predictor of unsatisfactory clinical outcome (OR = 5.51).

CONCLUSIONS

Satisfactory objective and subjective clinical outcomes were disclosed in about half of the patients with mild-to-moderate LSS in a 12-year follow-up. The number of comorbid diseases had an unfavourable effect on subjective evaluation of clinical outcome. The lowest transverse diameter of spinal canal proved to be the only independent predictor of deterioration of clinical status in LSS patients.

摘要

目的

这项前瞻性观察队列研究的目的是评估轻至中度腰椎管狭窄症(LSS)患者的长期预后,并分析临床预后的预测因素。

方法

对一组53例患者在中位时间139个月后进行复查。评估主观临床预后、客观临床预后及其预测因素、主观和客观预后之间的任何相关性,以及12年后放射学和电生理参数变化的发展情况。

结果

分别有54.7%和43.4%的患者记录到满意的客观和主观临床预后。未发现客观和主观临床预后之间存在统计学显著相关性(斯皮尔曼系数=0.225,p=0.132)。主观预后不满意的孤立患者在所有亚组中表现出最高的功能合并症指数。12年随访后,电生理和放射学检查结果未显示出统计学显著变化。多因素逻辑回归仅确认椎管最低横径≤13.6mm是临床预后不满意的独立预测因素(OR=5.51)。

结论

在12年的随访中,约一半的轻至中度LSS患者显示出满意的客观和主观临床预后。合并症的数量对临床预后的主观评估有不利影响。椎管最低横径被证明是LSS患者临床状况恶化的唯一独立预测因素。

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