Marcuard S P, Stegall K L, Trogdon S
Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
JPEN J Parenter Enteral Nutr. 1989 Jan-Feb;13(1):81-3. doi: 10.1177/014860718901300181.
This is a report of an in vitro study evaluating the ability of six solutions to dissolve clotted enteral feeding, which can cause feeding tube occlusion. The following clotted enteral feeding products were tested: Ensure Plus, Ensure Plus with added protein (Promod 20 g/liter), Osmolite, Enrich, and Pulmocare. Clot dissolution was then tested by adding Adolf's Meat Tenderizer, Viokase, Sprite, Pepsi, Coke, or Mountain Dew. Distilled water served as control. Dissolution score for each mixture was assessed blindly. Best dissolution was observed with Viokase in pH 7.9 solution (p less than 0.01). Similar results were obtained when feeding tube patency was restored in eight in vitro occluded feeding tubes (Dobbhoff, French size 8) by using first Pepsi (two/eight successful) and then Viokase in pH 7.9 (six/six successful). We also report our experience in the first 10 patients with occluded feeding tubes using this Viokase solution injected through a Drum catheter into the feeding tube. In seven patients, this method proved to be successful, and the reasons for failure in three patients include a knotted tube, impacted tablet powder, and a formula clot fo 24 hr duration and 45 cm in length.
这是一项体外研究报告,评估六种溶液溶解可导致喂养管堵塞的凝结肠内营养制剂的能力。测试了以下凝结肠内营养产品:安素益力佳、添加蛋白质的安素益力佳(每升含普诺得20克)、能全力、瑞先和益肺佳。然后通过添加阿道夫嫩肉粉、胰酶、雪碧、百事可乐、可口可乐或激浪来测试凝块溶解情况。蒸馏水作为对照。对每种混合物的溶解分数进行盲法评估。在pH 7.9的溶液中,胰酶的溶解效果最佳(p小于0.01)。当使用百事可乐(2/8成功),然后使用pH 7.9的胰酶(6/6成功)恢复八根体外堵塞的喂养管(多布霍夫管,8号法式尺寸)的通畅时,也得到了类似的结果。我们还报告了在首批10例喂养管堵塞患者中,通过鼓形导管将这种胰酶溶液注入喂养管的经验。在7例患者中,该方法被证明是成功的,3例患者失败的原因包括管子打结、片剂粉末结块以及持续24小时、长度为45厘米的配方凝块。