Wohlrab Johannes, Wohlrab David, Wohlrab Lukas, Wohlrab Christiane, Wohlrab Angelika
Department of Dermatology and Venereology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Skin Pharmacol Physiol. 2014;27(5):276-82. doi: 10.1159/000360545. Epub 2014 Jun 18.
Endogenous hyaluronidases in the human body have physiological and pathophysiological significance due to their enzymatic activity during the cleavage of hyaluronan. The potential of therapeutic use of testicular and recombinant hyaluronidase has been increasingly acknowledged and developed in recent years. Most relevant in practice is the co-application of hyaluronidase and other active substances in order to enhance their bioavailability within the tissue.
由于人体内源性透明质酸酶在透明质酸裂解过程中的酶活性，它们具有生理和病理生理意义。近年来，睾丸透明质酸酶和重组透明质酸酶的治疗应用潜力得到了越来越多的认可和发展。在实践中，最相关的是透明质酸酶与其他活性物质的联合应用，以提高它们在组织内的生物利用度。
