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一种新型多药联合疗法:治疗累及面部的局限性皮肤型系统性硬化症的新方法。

A neoteric multidrug combination: novel approach to limited cutaneous systemic scleroderma involving the face.

作者信息

Kumar M Hari, Kumar M Siva, Kumar Sabitha Hari, Kumar Kingsly Selva

机构信息

Dental Department, Jeba Dental Clinic, Nagercoil, Tamilnadu, India.

Department of Maxillo Facial, Doctor Kamalkanadasan Dental Clinic, Chennai, Tamilnadu, India.

出版信息

BMJ Case Rep. 2016 Mar 31;2016:bcr2015212787. doi: 10.1136/bcr-2015-212787.

DOI:10.1136/bcr-2015-212787
PMID:27033280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4840643/
Abstract

Limited cutaneous scleroderma is a subtype of scleroderma limited to the skin of the face, hands, feet and forearms. We present a case of a 45-year-old woman affected by limited cutaneous systemic scleroderma involving the orofacial region and causing restricted mouth opening. The patient showed noteworthy improvement of the skin lesion by use of a combination of intralesional corticosteroid with hyaluronidase and various multiantioxidants, resulting in amelioration of her mouth opening problem. The patient gave her full informed written consent to this report being published.

摘要

局限性皮肤型硬皮病是硬皮病的一种亚型,局限于面部、手部、足部和前臂的皮肤。我们报告一例45岁女性患者,患有累及口面部区域的局限性皮肤系统性硬皮病,并导致张口受限。通过病灶内注射皮质类固醇与透明质酸酶及多种抗氧化剂联合使用,患者皮肤病变有显著改善,张口问题也得到缓解。患者已书面签署知情同意书,同意发表本报告。

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A neoteric multidrug combination: novel approach to limited cutaneous systemic scleroderma involving the face.一种新型多药联合疗法:治疗累及面部的局限性皮肤型系统性硬化症的新方法。
BMJ Case Rep. 2016 Mar 31;2016:bcr2015212787. doi: 10.1136/bcr-2015-212787.
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[Observations of the course of scleroderma after combined Hylase-carnitine therapy].
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Severe Acro-osteolysis in a Case of Limited Cutaneous Scleroderma.局限性皮肤型硬皮病病例中的严重肢端骨质溶解
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本文引用的文献

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Corticosteroids in Myositis and Scleroderma.皮质类固醇在肌炎和硬皮病中的应用
Rheum Dis Clin North Am. 2016 Feb;42(1):103-18, ix. doi: 10.1016/j.rdc.2015.08.011. Epub 2015 Oct 26.
2
Corticosteroids: Mechanisms of Action in Health and Disease.皮质类固醇:健康与疾病中的作用机制
Rheum Dis Clin North Am. 2016 Feb;42(1):15-31, vii. doi: 10.1016/j.rdc.2015.08.002.
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Parry-Romberg syndrome with ipsilateral hemipons involvement presenting as monoplegic ataxia.伴有同侧脑桥受累的帕里-龙贝格综合征,表现为单瘫性共济失调。
Korean J Pediatr. 2015 Sep;58(9):354-7. doi: 10.3345/kjp.2015.58.9.354. Epub 2015 Sep 21.
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Acquired facial lipoatrophy: pathogenesis and therapeutic options.获得性面部脂肪萎缩:发病机制与治疗选择。
Postepy Dermatol Alergol. 2015 Apr;32(2):127-33. doi: 10.5114/pdia.2014.40971. Epub 2015 Mar 30.
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Oxidative damage and antioxidative therapy in systemic sclerosis.系统性硬化症中的氧化损伤与抗氧化治疗
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Use of hyaluronidase for pharmacokinetic increase in bioavailability of intracutaneously applied substances.使用透明质酸酶提高皮内给药物质的生物利用度的药代动力学研究。
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Role of the free radical release process in the pathogenesis of morphea in contrast to systemic sclerosis.游离基释放过程在硬斑病发病机制中的作用与系统性硬皮病相反。
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Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition.番茄红素抑制癌症的多种分子和细胞作用机制。
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Systemic sclerosis: current concepts in pathogenesis and therapeutic aspects of dermatological manifestations.系统性硬化症:皮肤病学表现的发病机制和治疗方面的当前概念
Indian J Dermatol. 2013 Jul;58(4):255-68. doi: 10.4103/0019-5154.113930.
10
My approach to the treatment of scleroderma.我治疗硬皮病的方法。
Mayo Clin Proc. 2013 Apr;88(4):377-93. doi: 10.1016/j.mayocp.2013.01.018.