Feely Michael M, Gonzalo David H, Corbera Montserrat, Hughes Steven J, Trevino Jose G
Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
J Gastrointest Surg. 2014 Sep;18(9):1710-5. doi: 10.1007/s11605-014-2568-3. Epub 2014 Jun 19.
An increased awareness of IgG4-related diseases has led to an escalation in the number of sites known to be involved by this fibroinflammatory disease. We report three cases of IgG4-related cholecystitis which were thought to represent biliary malignancies both clinically and radiographically. All three cases underwent surgery tailored towards presumed malignant neoplasms. Only following pathologic examination was the true nature of the disease identified. Recognition of the clinical, radiographic, and pathologic presentation of IgG4-related cholecystitis is essential for the consideration of this disease process prior to surgical management for suspected gallbladder malignancies. However, the pre-operative diagnosis remains challenging and extensive surgical intervention is often necessary given the distressing presentation of IgG4-related cholecystitis.
对IgG4相关疾病认识的提高，导致已知受这种纤维炎症性疾病累及的部位数量增加。我们报告了3例IgG4相关胆囊炎病例，这些病例在临床和影像学上均被认为是胆道恶性肿瘤。所有3例均接受了针对假定恶性肿瘤的手术。仅在病理检查后才确定了疾病的真正性质。认识IgG4相关胆囊炎的临床、影像学和病理表现，对于在疑似胆囊恶性肿瘤的手术治疗前考虑这一疾病过程至关重要。然而，术前诊断仍然具有挑战性，鉴于IgG4相关胆囊炎令人痛苦的表现，往往需要进行广泛的手术干预。
