Rosselli F, Moustacchi E
Institut Curie, Section de Biologie, Paris, France.
Mutat Res. 1989 Mar;225(3):115-9. doi: 10.1016/0165-7992(89)90127-9.
After exposure to mitomycin C, the mouse lymphoma cell mutant MCN-151, previously shown to be sensitive to the toxic effect of the drug, demonstrates higher frequencies of chromatid-type aberrations and of aberrant cells in comparison to L5178Y cells. At any given dose of mitomycin C, the frequencies of chromosomal aberrations increased with time reaching a plateau in both cell strains, with the mutant in all cases being more sensitive than normal cells.
在接触丝裂霉素C后，先前已证明对该药物的毒性作用敏感的小鼠淋巴瘤细胞突变体MCN - 151，与L5178Y细胞相比，表现出更高频率的染色单体型畸变和异常细胞。在任何给定剂量的丝裂霉素C下，两个细胞株中染色体畸变的频率均随时间增加并达到平稳状态，在所有情况下突变体均比正常细胞更敏感。
