Li Shouzhen, Cao Xueyuan, Jiang Chengyi, Wang Quan
Department of Gastrointestinal Surgery, First Bethune Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Oncol Lett. 2014 Apr;7(4):953-955. doi: 10.3892/ol.2014.1825. Epub 2014 Jan 24.
Neuroendocrine carcinoma and adenocarcinoma existing in the stomach simultaneously is extremely rare. This report presents a 65-year-old male patient who was diagnosed with three types of malignant tumors in the stomach, neuroendocrine carcinoma (NEC), moderately differentiated adenocarcinoma and mucinous adenocarcinoma. In addition, the NEC and moderately differentiated adenocarcinoma existed in the same lesion and, therefore, was referred to as a mixed adenocarcinoma - NEC tumor. The patient underwent laparoscopic-assisted D2 radical total gastrectomy, Roux-en-Y esophagus-jejunum anastomosis and received FOLFOX chemotherapy for six cycles 3 weeks after surgery. Follow-up determined that the patient survived and was tumor-free 12 months after surgery. In conclusion, radical surgery combined with chemotherapy can effectively improve the prognosis of patients with these three specific tumor types simultaneously in the stomach.
胃内同时存在神经内分泌癌和腺癌极为罕见。本报告介绍了一名65岁男性患者，其被诊断出胃内有三种恶性肿瘤，即神经内分泌癌（NEC）、中分化腺癌和黏液腺癌。此外，NEC和中分化腺癌存在于同一病灶，因此被称为混合性腺癌-NEC肿瘤。该患者接受了腹腔镜辅助D2根治性全胃切除术、Roux-en-Y食管空肠吻合术，并在术后3周接受了6个周期的FOLFOX化疗。随访确定患者术后12个月存活且无肿瘤。总之，根治性手术联合化疗可有效改善胃内同时存在这三种特定肿瘤类型患者的预后。
