人嗜T细胞病毒I型感染的T细胞系中HMGB1的大量表达以及成人T细胞白血病患者血浆中HMGB1的高水平。
Abundant expression of HMGB1 in human T-cell lymphotropic virus type I-infected T-cell lines and high plasma levels of HMGB1 in patients with adult T-cell leukemia.
作者信息
Kimura Ryuichiro, Mori Naoki
机构信息
Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan ; Transdisciplinary Research Organization for Subtropics and Island Studies, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan.
出版信息
Oncol Lett. 2014 Apr;7(4):1239-1242. doi: 10.3892/ol.2014.1851. Epub 2014 Feb 3.
High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels in patients with adult T-cell leukemia [ATL; which is caused by infection with human T-cell lymphotropic virus type I (HTLV-I)] compared with normal controls. In addition, HMGB1 was highly expressed in HTLV-I-infected T-cell lines compared with uninfected T-cell lines. The HTLV-I oncoprotein, Tax, induced extracellular release of HMGB1 in T cells. The results suggest that HMGB1 is a potential biomarker and a therapeutic target for ATL.
高迁移率族蛋白B1（HMGB1）作为一种与染色质相关的核蛋白和细胞外信号分子发挥作用。分别通过酶联免疫吸附测定（ELISA）和聚合酶链反应（PCR）分析HMGB1蛋白的浓度和HMGB1信使核糖核酸（mRNA）的表达。本研究报告称，与正常对照相比，成人T细胞白血病（ATL；由I型人类嗜T细胞病毒（HTLV-I）感染引起）患者的血浆HMGB1水平较高。此外，与未感染的T细胞系相比，HMGB1在HTLV-I感染的T细胞系中高表达。HTLV-I癌蛋白Tax诱导T细胞中HMGB1的细胞外释放。结果表明，HMGB1是ATL的潜在生物标志物和治疗靶点。
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