Universidad El Bosque, Vice-Chancellor of Research, Virology Group, Bogotá 110121, Colombia.
Viruses. 2022 Aug 12;14(8):1765. doi: 10.3390/v14081765.
Dengue is a viral infection caused by dengue virus (DENV), which has a significant impact on public health worldwide. Although most infections are asymptomatic, a series of severe clinical manifestations such as hemorrhage and plasma leakage can occur during the severe presentation of the disease. This suggests that the virus or host immune response may affect the protective function of endothelial barriers, ultimately being considered the most relevant event in severe and fatal dengue pathogenesis. The mechanisms that induce these alterations are diverse. It has been suggested that the high mobility group box 1 protein (HMGB1) may be involved in endothelial dysfunction. This non-histone nuclear protein has different immunomodulatory activities and belongs to the alarmin group. High concentrations of HMGB1 have been detected in patients with several infectious diseases, including dengue, and it could be considered as a biomarker for the early diagnosis of dengue and a predictor of complications of the disease. This review summarizes the main features of dengue infection and describes the known causes associated with endothelial dysfunction, highlighting the involvement and possible relationship between HMGB1 and DENV.
登革热是由登革病毒（DENV）引起的一种病毒性感染，对全球公共卫生有重大影响。尽管大多数感染是无症状的，但在疾病的严重表现期间，可能会出现一系列严重的临床表现，如出血和血浆渗漏。这表明病毒或宿主免疫反应可能会影响内皮屏障的保护功能，最终被认为是严重和致命登革热发病机制中最相关的事件。诱导这些改变的机制是多种多样的。有人提出，高迁移率族蛋白 1（HMGB1）可能参与内皮功能障碍。这种非组蛋白核蛋白具有不同的免疫调节活性，属于警报素组。在包括登革热在内的几种传染病患者中，已经检测到高浓度的 HMGB1，它可以被认为是登革热早期诊断的生物标志物和疾病并发症的预测因子。这篇综述总结了登革热感染的主要特征，并描述了已知与内皮功能障碍相关的原因，强调了 HMGB1 和 DENV 的参与和可能的关系。
