Moriyama Shingo, Takeshita Hideki, Adachi Akiko, Arai Yoshiaki, Higuchi Saori, Tokairin Takuo, Chiba Koji, Nakagawa Koji, Noro Akira
Department of Urology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
Department of Pathology, Saitama Red Cross Hospital, Saitama, Saitama 338-8553, Japan.
Oncol Lett. 2014 Apr;7(4):1273-1275. doi: 10.3892/ol.2014.1830. Epub 2014 Jan 27.
Metastasis from renal cell carcinoma (RCC) to the testis is rare. This case report presented an extremely rare case of simultaneous bilateral testicular metastases from RCC in a 65-year-old man who had experienced indolent scrotal enlargement over a period of several months. Scrotal ultrasonography showed 4.0- and 2.0-cm-sized masses in the left and right testes, respectively. Contrast-enhanced computed tomography identified multiple tumors in the kidneys, the pancreas and the left adrenal gland. Left orchiectomy and pathological examination were performed and indicated testicular metastasis from clear cell RCC. The patient underwent complete surgical resection of all residual lesions. Postoperative follow-up examination without adjuvant therapy identified no recurrence over 11 months. This study also reviewed existing literature and determined that retrograde venous spread from the primary kidney tumor to the testis may be an important pathway for testicular metastasis from RCC. In conclusion, RCC can result in testicular metastases not only unilaterally, but also bilaterally, as was observed in the present case.
肾细胞癌（RCC）转移至睾丸较为罕见。本病例报告呈现了一例极为罕见的65岁男性同时发生双侧睾丸转移的RCC病例，该患者在数月内阴囊逐渐无痛性肿大。阴囊超声检查显示左侧和右侧睾丸分别有4.0厘米和2.0厘米大小的肿块。增强计算机断层扫描发现肾脏、胰腺和左侧肾上腺有多个肿瘤。进行了左侧睾丸切除术及病理检查，结果显示为透明细胞RCC睾丸转移。患者接受了所有残留病灶的完整手术切除。术后未进行辅助治疗的随访检查显示，11个月内未复发。本研究还回顾了现有文献，确定原发性肾肿瘤经逆行静脉播散至睾丸可能是RCC睾丸转移的重要途径。总之，如本病例所示，RCC不仅可导致单侧睾丸转移，也可导致双侧睾丸转移。
