一种抗血管生成糖胺聚糖的化学合成
Chemogenesis of an antiangiogenic glycosaminoglycan.
作者信息
Raman Karthik, Arungundram Sailaja, Kuberan Balagurunathan
机构信息
Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, United States.
Department of Medicinal Chemistry, University of Utah , Salt Lake City, Utah 84112, United States.
出版信息
ACS Med Chem Lett. 2014 Apr 4;5(6):644-6. doi: 10.1021/ml400498d. eCollection 2014 Jun 12.
Abstract
In this letter we report a facile chemical conversion of heparin, a potent anticoagulant with minimal antiangiogenic activity, into an effective antiangiogenic glycosaminoglycan through optimized chemical approaches. This work highlights the potential for industrial scale production of a therapeutic anticancer glycosaminoglycan.
摘要
在本信函中，我们报告了一种简便的化学方法，可将肝素（一种具有最小抗血管生成活性的强效抗凝剂）通过优化的化学途径转化为一种有效的抗血管生成糖胺聚糖。这项工作突出了治疗性抗癌糖胺聚糖进行工业规模生产的潜力。
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