银结合核仁组织区点在伴有上皮发育异常的口腔白斑及口腔鳞状细胞癌中的研究：一项体内研究
Silver binding nucleolar organizer regions dots in oral leukoplakia with epithelial dysplasia and oral squamous cell carcinoma: an in vivo study.
作者信息
Mansoor Samadi Fahad, Thattil Sebastian Bastain, Singh Anil, Chandra Shaleen, Mohammad Shadab, Singh Arun, Halappa Thippeswamy, Samadi Firoza
机构信息
Department of Oral Pathology & Microbiology, King George's Medical University, Lucknow, India.
Department of Oral Pathology & Microbiology, Mahe Institute of Dental Sciences, Palloor, Mahe, Puducherry, India.
出版信息
ISRN Dent. 2014 Apr 30;2014:479187. doi: 10.1155/2014/479187. eCollection 2014.
Silver binding nucleolar organizer regions (AgNOR) in normal oral mucosa (NOM), oral leukoplakia with epithelial dysplasia (ED), and oral squamous cell carcinoma (OSCC) were studied. The mean AgNOR count per nucleus increased from NOM to ED to OSCC. Tissue showing ED in oral leukoplakia and OSCC cases showed higher counts, wider scatter, and smaller size of AgNOR dots in the nuclei. The study seems to suggest that time method has some potential in distinguishing between NOM and oral leukoplakia with ED and OSCC. Studies of larger numbers are needed to arrive at more substantial conclusions.
对正常口腔黏膜（NOM）、伴有上皮发育异常（ED）的口腔白斑和口腔鳞状细胞癌（OSCC）中的银结合核仁组织区（AgNOR）进行了研究。每个细胞核的平均AgNOR计数从NOM到ED再到OSCC逐渐增加。在口腔白斑和OSCC病例中显示有ED的组织，其细胞核中的AgNOR计数更高、散点更宽且AgNOR点的尺寸更小。该研究似乎表明，计时方法在区分NOM与伴有ED的口腔白斑及OSCC方面具有一定潜力。需要进行更多数量的研究才能得出更确凿的结论。
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