mTORC2，即“另一种”mTOR，是能量平衡调节中的新成员。 - Suppr | 超能文献

mTORC2, the "other" mTOR, is a new player in energy balance regulation.

作者信息

Cota Daniela

机构信息

INSERM, Neurocentre Magendie, Physiophatologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France ; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France.

出版信息

Mol Metab. 2014 Apr 18;3(4):349-50. doi: 10.1016/j.molmet.2014.04.002. eCollection 2014 Jul.

DOI:10.1016/j.molmet.2014.04.002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4060211/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e7f/4060211/ad0d77247d9f/gr1.jpg

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Hypothalamic mTOR: the rookie energy sensor.下丘脑哺乳动物雷帕霉素靶蛋白：新晋能量传感器。

Curr Mol Med. 2014 Jan;14(1):3-21. doi: 10.2174/1566524013666131118103706.

3

mTOR complexes in neurodevelopmental and neuropsychiatric disorders.mTOR 复合物在神经发育和神经精神疾病中的作用。

Nat Neurosci. 2013 Nov;16(11):1537-43. doi: 10.1038/nn.3546. Epub 2013 Oct 28.

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J Cell Biol. 2013 Apr 15;201(2):293-308. doi: 10.1083/jcb.201205030. Epub 2013 Apr 8.

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Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons.哺乳动物雷帕霉素靶蛋白复合物 1（mTORC1）和 2（mTORC2）控制海马神经元树突分支形态。

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