Man Bik Ling, Fu Yat Pang
Bik Ling Man, Yat Pang Fu, Division of Neurology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China.
World J Clin Cases. 2014 Jun 16;2(6):201-5. doi: 10.12998/wjcc.v2.i6.201.
Atherosclerosis of cerebral vessels is a common cause of stroke. Racial differences in the distribution of cerebrovascular occlusive disease are well documented. Extracranial stenosis is more common in Caucasians, while intracranial stenosis is more common in Asians, Hispanics and African-Americans. Concurrent atherosclerosis of extracranial and intracranial vessels is common in Asians. The incidence of concurrent stenoses ranges from 10% to 48% in patients with symptomatic cerebrovascular disease. The long-term prognosis of these patients is poor and they are at high risk of further vascular events or death. The purpose of this review is to examine the epidemiology, risk factors, stroke mechanism and genetics of concurrent stenoses and to discuss strategies for treatment.
脑血管动脉粥样硬化是中风的常见病因。脑血管闭塞性疾病分布的种族差异已有充分记录。颅外狭窄在白种人中更为常见，而颅内狭窄在亚洲人、西班牙裔和非裔美国人中更为常见。亚洲人颅外和颅内血管同时发生动脉粥样硬化很常见。在有症状的脑血管疾病患者中，同时存在狭窄的发生率在10%至48%之间。这些患者的长期预后较差，发生进一步血管事件或死亡的风险很高。本综述的目的是研究同时存在狭窄的流行病学、危险因素、中风机制和遗传学，并讨论治疗策略。
