Lin Yin, Jeng Long-Bin, Wang Hsin-Yi, Tsai Shih-Chuan, Lin Wan-Yu, Kao Chia-Hung
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan Yin Lin and Wan-Yu Lin contributed equally to this work.
Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan.
Technol Cancer Res Treat. 2015 Oct;14(5):593-9. doi: 10.7785/tcrt.2012.500438. Epub 2014 Nov 26.
The purpose of this study was to evaluate the accuracy of (18)F-FDG PET/CT scans in detecting adrenal metastasis in liver transplant candidates with hepatocellular carcinoma (HCC). A total of 166 patients diagnosed with HCC received (18)F-FDG PET/CT imaging before liver transplantation. Of these patients, 5 patients (4 males, 1 female; median age: 51.2 y, range: 33-61 y) were found to have suspected adrenal metastases and were included in this study. Two cases (Cases 1 and 5) underwent an (18)F-FDG PET/CT scan at the initial stage, 3 cases (Cases 2-4) underwent an (18)F-FDG PET/CT scan for restaging, and one case (Case 5) underwent a second (18)F-FDG PET/CT scan for evaluating treatment response. Among the 8 lesions, there was one false-negative metastatic lesion (Lesion 4, Case 3) and one false-positive adrenal gland lesion (Lesion 7, Case 5) when compared with either histopathologic reports or established clinical and imaging follow-up results. In general, (18)F-FDG PET/CT scans have limitations that make it difficult to distinguish between malignant and benign lesions in adrenal glands that are based only on quantitative values measured using the (18)F-FDG PET/CT scan.
本研究的目的是评估氟代脱氧葡萄糖（18F-FDG）正电子发射断层显像/X线计算机体层成像（PET/CT）扫描检测肝细胞癌（HCC）肝移植受者肾上腺转移的准确性。共有166例诊断为HCC的患者在肝移植前接受了18F-FDG PET/CT成像。在这些患者中，有5例（4例男性，1例女性；中位年龄：51.2岁，范围：33 - 61岁）被发现有疑似肾上腺转移，并纳入本研究。2例（病例1和病例5）在初始阶段接受了18F-FDG PET/CT扫描，3例（病例2 - 4）接受了18F-FDG PET/CT扫描用于再分期，1例（病例5）接受了第二次18F-FDG PET/CT扫描用于评估治疗反应。与组织病理学报告或既定的临床及影像学随访结果相比，8个病灶中有1个假阴性转移病灶（病例3中的病灶4）和1个假阳性肾上腺病灶（病例5中的病灶7）。总体而言，18F-FDG PET/CT扫描存在局限性，仅基于18F-FDG PET/CT扫描测量的定量值难以区分肾上腺的恶性和良性病变。
