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分泌囊泡将Cdc42p转运至酿酒酵母的极性生长位点。

Secretory vesicles deliver Cdc42p to sites of polarized growth in S. cerevisiae.

作者信息

Dighe Shubha A, Kozminski Keith G

机构信息

Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America.

Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America; Department of Cell Biology, University of Virginia, Charlottesville, Virginia, United States of America.

出版信息

PLoS One. 2014 Jun 19;9(6):e99494. doi: 10.1371/journal.pone.0099494. eCollection 2014.

DOI:10.1371/journal.pone.0099494
PMID:24945395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4063767/
Abstract

The activation and localization of the Rho-family GTPase Cdc42p at one pole of a cell is necessary for maintaining an axis of polarized growth in many animal and fungal cells. How the asymmetric distribution of this key regulator of polarized morphogenesis is maintained is not fully understood, though divergent models have emerged from a congruence of multiple studies, including one that posits a role for polarized secretion. Here we show with S. cerevisiae that Cdc42p associates with secretory vesicles in vivo.

摘要

Rho家族GTP酶Cdc42p在细胞一极的激活和定位对于许多动物和真菌细胞维持极化生长轴是必需的。尽管多项研究的结果产生了不同的模型，包括一种认为极化分泌起作用的模型，但对于这种极化形态发生关键调节因子的不对称分布是如何维持的，我们还没有完全理解。在这里，我们用酿酒酵母表明，Cdc42p在体内与分泌囊泡相关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/4063767/e39169eb965b/pone.0099494.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/4063767/d250626ca6ae/pone.0099494.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/4063767/0828f325a2e4/pone.0099494.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/4063767/e39169eb965b/pone.0099494.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/4063767/d250626ca6ae/pone.0099494.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/4063767/0828f325a2e4/pone.0099494.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9178/4063767/e39169eb965b/pone.0099494.g003.jpg

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