乌干达用于口腔护理的药用植物提取物的抗菌活性。
Antibacterial activities of extracts from Ugandan medicinal plants used for oral care.
作者信息
Ocheng Francis, Bwanga Freddie, Joloba Moses, Borg-Karlson Ann-Karin, Gustafsson Anders, Obua Celestino
机构信息
Department of Dentistry, School of Health Sciences, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda; Department of Medical Microbiology, School of Biomedical Sciences College of Health Sciences, Makerere University, P.O. Box 7072 Kampala, Uganda; Unit of Periodontology, Department of Dental Medicine, Karolinska Institutet, P.O. Box, 4064, SE-141 04, Huddinge, Sweden.
Department of Medical Microbiology, School of Biomedical Sciences College of Health Sciences, Makerere University, P.O. Box 7072 Kampala, Uganda.
出版信息
J Ethnopharmacol. 2014 Aug 8;155(1):852-5. doi: 10.1016/j.jep.2014.06.027. Epub 2014 Jun 16.
ETHNOPHARMACOLOGICAL RELEVANCE
Medicinal plants are widely used for treatment of oral/dental diseases in Uganda.
AIM OF THE STUDY
To investigate antibacterial activities of 16 commonly used medicinal plants on microorganisms associated with periodontal diseases (PD) and dental caries (DC).
MATERIALS AND METHODS
Pulp juice and solvent extracts (hexane, methanol and water) from the plants were tested against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia associated with PD and Streptococcus mutans, Streptococcus sobrinus, Lactobacillus acidophilus associated with DC. Tests were done using agar well-diffusion (pulp juice) and agar-dilution (Solvent extracts) assays.
RESULTS
Pulp juice from Zanthoxylum chalybeum and Euclea latidens showed activity against all the bacteria, Zanthoxylum chalybeum being most active. Hexane extract from aerial part of Helichrysum odoratissimum was most active (MIC: 0.125-0.5 mg/ml). Methanol extract from leaves of Lantana trifolia showed activity against all bacteria (MIC: 0.25-1 mg/ml).
CONCLUSION
Several of the tested plants showed antibacterial activities against bacteria associated with PD and DC, meriting further investigations.
民族药理学相关性
药用植物在乌干达被广泛用于治疗口腔/牙齿疾病。
研究目的
研究16种常用药用植物对与牙周疾病（PD）和龋齿（DC）相关的微生物的抗菌活性。
材料与方法
测试了这些植物的果肉汁和溶剂提取物（己烷、甲醇和水）对与PD相关的伴放线聚集杆菌、牙龈卟啉单胞菌、福赛坦氏菌以及与DC相关的变形链球菌、远缘链球菌、嗜酸乳杆菌的抗菌活性。采用琼脂孔扩散法（果肉汁）和琼脂稀释法（溶剂提取物）进行测试。
结果
花椒和宽叶核果木的果肉汁对所有细菌均有活性，花椒的活性最强。蜡菊地上部分的己烷提取物活性最强（最低抑菌浓度：0.125 - 0.5毫克/毫升）。马缨丹叶的甲醇提取物对所有细菌均有活性（最低抑菌浓度：0.25 - 1毫克/毫升）。
结论
几种受试植物对与PD和DC相关的细菌显示出抗菌活性，值得进一步研究。
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