Khochtali Sana, Abroug Nesrine, Kahloun Rim, Ksiaa Imen, Nahdi Imen, Zaouali Sonia, Ben Yahia Salim, Khairallah Moncef
a Department of Ophthalmology , Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir , Monastir , Tunisia.
Ocul Immunol Inflamm. 2015;23(5):371-7. doi: 10.3109/09273948.2014.925125. Epub 2014 Jun 19.
To describe the pattern of acute retinal necrosis (ARN) syndrome in a referral center in Tunisia.
Retrospective review of the charts of 12 patients (12 eyes).
Necrotizing retinitis involved >50% of the retina in 33.3% of eyes. Polymerase chain reaction on aqueous humor sample identified herpes simplex virus-1 in 4 eyes (33.3%) and varicella zoster virus in 3 eyes (25%), and was negative in 5 eyes (41.7%). All patients received intravenous acyclovir, followed by oral antivirals. Follow-up ranged from 6 to 16 months. Retinal detachment (RD) occurred in 3 eyes (25%), but no patient developed bilateral ARN. Final visual acuity was 20/200 or worse in 7 eyes (58.3%). Delay in diagnosis (p = 0.015), macular involvement (p = 0.045), development of RD (p = 0.018), and 25-50% of retinal involvement (p = 0.045) were associated with a worse visual outcome.
ARN carries poor visual prognosis in Tunisia.
描述突尼斯一家转诊中心急性视网膜坏死（ARN）综合征的发病模式。
回顾性分析12例患者（12只眼）的病历。
33.3%的患眼中坏死性视网膜炎累及超过50%的视网膜。房水样本的聚合酶链反应在4只眼（33.3%）中检测出单纯疱疹病毒1型，3只眼（25%）中检测出水痘带状疱疹病毒，5只眼（41.7%）检测结果为阴性。所有患者均接受静脉注射阿昔洛韦治疗，随后口服抗病毒药物。随访时间为6至16个月。3只眼（25%）发生视网膜脱离（RD），但无患者发生双侧ARN。7只眼（58.3%）的最终视力为20/200或更差。诊断延迟（p = 0.015）、黄斑受累（p = 0.045）、发生RD（p = 0.018）以及视网膜受累25%-50%（p = 0.045）与较差的视力预后相关。
在突尼斯，ARN的视力预后较差。
