Bager Palle, Dahlerup Jens F
Department of Hepatology and Gastroenterology, Aarhus University Hospital , Aarhus C , Denmark.
Scand J Gastroenterol. 2014 Aug;49(8):909-16. doi: 10.3109/00365521.2014.910544. Epub 2014 Jun 19.
Nonvariceal acute upper gastrointestinal bleeding (AUGIB) is often associated with significant blood loss and anemia. Both the bleeding episode itself and the subsequent anemia are likely to significantly impact a patient's health-related quality of life (HRQoL). Treating the anemia is essential to increase the hemoglobin levels. The HRQoL impact has not been investigated. This longitudinal study aimed to determine the relationship between anemia, HRQoL, and fatigue in patients after nonvariceal AUGIB.
A total of 97 patients (51 males and 46 females; mean age 70 years) were followed in a longitudinal study with a 6-month follow-up. All patients had AUGIB and were anemic at inclusion. Anemia, HRQoL (EQ-5D-3L), and fatigue (using the Multidimensional Fatigue Inventory) were assessed at baseline, and at 1, 3, and 6 months. The patients were initially included in an iron supplementation study.
The patients' HRQoL increased and their fatigue levels decreased from baseline to month 3 and month 6. Approximately half of the patients had full health at month 3; similar results were observed in the general population. Three and six months after the bleeding episodes, neither the HRQoL nor fatigue was affected by the anemia.
This study did not uncover relationships between anemia and HRQoL or anemia and fatigue after nonvariceal AUGIB.
非静脉曲张性急性上消化道出血（AUGIB）常伴有大量失血和贫血。出血事件本身以及随后的贫血都可能对患者的健康相关生活质量（HRQoL）产生重大影响。治疗贫血对于提高血红蛋白水平至关重要。尚未对HRQoL的影响进行研究。这项纵向研究旨在确定非静脉曲张性AUGIB患者贫血、HRQoL和疲劳之间的关系。
在一项为期6个月随访的纵向研究中，共纳入97例患者（51例男性和46例女性；平均年龄70岁）。所有患者均患有AUGIB，纳入时均为贫血。在基线、1个月、3个月和6个月时评估贫血、HRQoL（EQ-5D-3L）和疲劳（使用多维疲劳量表）。这些患者最初被纳入一项铁补充剂研究。
从基线到第3个月和第6个月，患者的HRQoL有所提高，疲劳水平有所下降。大约一半的患者在第3个月时健康状况良好；在普通人群中也观察到了类似结果。出血事件发生3个月和6个月后，贫血对HRQoL和疲劳均无影响。
本研究未发现非静脉曲张性AUGIB后贫血与HRQoL或贫血与疲劳之间的关系。
