产前和青春期前邻苯二甲酸盐和双酚A与男孩性激素及青春期的关系
Prenatal and peripubertal phthalates and bisphenol A in relation to sex hormones and puberty in boys.
作者信息
Ferguson Kelly K, Peterson Karen E, Lee Joyce M, Mercado-García Adriana, Blank-Goldenberg Clara, Téllez-Rojo Martha M, Meeker John D
机构信息
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
出版信息
Reprod Toxicol. 2014 Aug;47:70-6. doi: 10.1016/j.reprotox.2014.06.002. Epub 2014 Jun 16.
Phthalates and BPA are known endocrine disruptors and exposure in pregnant mothers and children is ubiquitous. We explored the relationship of prenatal and childhood exposures with pubertal onset and sex hormones in boys (ages 8-14). Phthalate metabolites and BPA were measured in maternal 3rd trimester or childhood urine. Sex hormones DHEAS, estradiol, inhibin B, SHBG, and total testosterone were measured in serum. Adrenarche and puberty were assessed by pediatrician. Prenatal exposure to some phthalates was associated with decreased DHEAS and inhibin B levels, and with increased SHBG. Prenatal exposure to most phthalates and BPA was associated with greatly reduced odds of adrenarche (odds ratios [OR]=0.12-0.65) and slightly reduced odds of puberty (OR=0.50-0.98). Childhood exposure was not associated with adrenarche or puberty, but some phthalates and BPA were associated with increased SHBG levels and decreased total and free testosterone levels.
邻苯二甲酸盐和双酚A是已知的内分泌干扰物，孕妇和儿童普遍接触到这些物质。我们探讨了产前和儿童期接触这些物质与8至14岁男孩青春期启动及性激素之间的关系。在孕妇孕晚期或儿童期尿液中检测邻苯二甲酸酯代谢物和双酚A。在血清中检测性激素硫酸脱氢表雄酮（DHEAS）、雌二醇、抑制素B、性激素结合球蛋白（SHBG）和总睾酮。由儿科医生评估肾上腺初现和青春期。产前接触某些邻苯二甲酸盐与DHEAS和抑制素B水平降低以及SHBG升高有关。产前接触大多数邻苯二甲酸盐和双酚A与肾上腺初现几率大幅降低（比值比[OR]=0.12 - 0.65）以及青春期几率略有降低（OR=0.50 - 0.98）有关。儿童期接触与肾上腺初现或青春期无关，但某些邻苯二甲酸盐和双酚A与SHBG水平升高以及总睾酮和游离睾酮水平降低有关。
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