孕期草甘膦和氨甲基膦酸尿浓度与早产的关系：MIREC研究
Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study.
作者信息
Ashley-Martin Jillian, Marro Leonora, Owen James, Borghese Michael M, Arbuckle Tye, Bouchard Maryse F, Lanphear Bruce, Walker Mark, Foster Warren, Fisher Mandy
机构信息
Environmental Health Research and Science Bureau, Health Canada, Ottawa, ON, Canada.
Armand-Frappier Santé Biotechnologie Research Centre, Institut National de la Recherche Scientifique, Laval, QC, Canada.
出版信息
J Expo Sci Environ Epidemiol. 2024 Sep 18. doi: 10.1038/s41370-024-00702-w.
BACKGROUND
Few high-quality studies have evaluated associations between urinary glyphosate or its environmental degradate (aminomethylphosphonic acid (AMPA)] and preterm birth (PTB).
OBJECTIVES
To quantify associations between urinary glyphosate and AMPA and preterm birth in the pan-Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) study and determine if associations differ by fetal sex.
METHODS
We measured first trimester urinary glyphosate and AMPA concentrations in MIREC participants who were recruited between 2008-2011 from 10 Canadian cities. Of the 1880 participants whose first trimester urine samples were analyzed for glyphosate or AMPA, 1765 delivered a singleton, live birth. Our primary outcome was preterm birth (PTB) defined as births occurring between 20 and <37 weeks. Secondary outcomes were spontaneous preterm births (sPTB) and gestational age. We modelled the hazard of PTB and sPTB using discrete time survival analysis with multivariable logistic regression to calculate odds ratios (OR). We used multivariable linear regression models to quantify associations between analytes and gestational age. To assess effect modification by fetal sex, we stratified all models and calculated interaction terms. In the logistic regressions models we additionally calculated the relative excess risk due to interaction.
RESULTS
Six percent (n = 106) of the study population delivered preterm, and 4.7% (n = 83) had a spontaneous preterm birth. Median specific-gravity standardized concentrations of glyphosate and AMPA were 0.25 and 0.21 µg/L. Associations between both glyphosate or AMPA and PTB, sPTB, and gestational age centered around the null value. The adjusted ORs of PTB for each doubling of glyphosate and AMPA concentrations were 0.98 (95% CI: 0.94, 1.03) and 0.99 (95% CI: 0.92, 1.06) respectively. We observed no evidence of differences by fetal sex.
CONCLUSIONS
In this Canadian pregnancy cohort, neither glyphosate nor AMPA urinary concentrations was associated with PTB or reduced gestational length.
背景
很少有高质量的研究评估尿中草甘膦或其环境降解产物（氨甲基膦酸（AMPA））与早产（PTB）之间的关联。
目的
在全加拿大母婴环境化学物质研究（MIREC）中，量化尿中草甘膦和AMPA与早产之间的关联，并确定关联是否因胎儿性别而异。
方法
我们测量了2008年至2011年期间从加拿大10个城市招募的MIREC参与者孕早期尿中草甘膦和AMPA的浓度。在1880名孕早期尿液样本进行草甘膦或AMPA分析的参与者中，1765名分娩了单胎活产儿。我们的主要结局是早产（PTB），定义为在20至<37周之间出生。次要结局是自发性早产（sPTB）和孕周。我们使用离散时间生存分析和多变量逻辑回归对PTB和sPTB的风险进行建模，以计算比值比（OR）。我们使用多变量线性回归模型量化分析物与孕周之间的关联。为了评估胎儿性别的效应修正，我们对所有模型进行分层并计算交互项。在逻辑回归模型中，我们还计算了交互作用导致的相对超额风险。
结果
研究人群中有6%（n = 106）早产，4.7%（n = 83）有自发性早产。草甘膦和AMPA的比重标准化浓度中位数分别为0.25和0.21μg/L。草甘膦或AMPA与PTB、sPTB和孕周之间的关联均集中在零值附近。草甘膦和AMPA浓度每增加一倍，PTB的校正OR分别为0.98（95%CI：0.94，1.03）和0.99（95%CI：0.92，1.06）。我们没有观察到因胎儿性别而异的证据。
结论
在这个加拿大孕妇队列中，尿中草甘膦和AMPA浓度均与PTB或孕周缩短无关。
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