Sawamura Daisuke, Ikoma Katsunori, Yoshida Kazuki, Inagaki Yuji, Ogawa Keita, Sakai Shinya
Division of Health Sciences, Graduate School of Health Sciences, Hokkaido University , Sapporo, Hokkaido , Japan .
Brain Inj. 2014;28(11):1455-60. doi: 10.3109/02699052.2014.919531. Epub 2014 Jun 19.
To examine active inhibition of irrelevant stimuli and evaluate its neural basis using functional near infrared spectroscopy in patients with attention deficits after traumatic brain injury (TBI).
Case control study.
Ten patients with TBI and 10 healthy control subjects participated in this study. The Paced Auditory Serial Addition Test (PASAT) was performed with (distracting PASAT) and without (PASAT) distracting Japanese kana phonetic characters presented between each number. A block design was used. Subjects alternately performed each task three times.
Healthy controls performed better than patients with TBI on both the tasks. When performing the PASAT, healthy controls showed significant activity in every region of interest except the right lateral prefrontal cortex (PFC), but patients with TBI showed significant activity only in the left anterior PFC and left lateral PFC. When performing the distracting PASAT, the right lateral PFC was active in healthy controls, but not in patients with TBI.
These results confirm that patients with moderate-to-severe TBI were affected by distractors that influenced order processing. It is suggested that the working memory of patients with TBI was affected by distracting stimuli, whereas that of healthy individuals was not.
使用功能近红外光谱技术，研究创伤性脑损伤（TBI）后注意力缺陷患者对无关刺激的主动抑制情况，并评估其神经基础。
病例对照研究。
10名TBI患者和10名健康对照者参与了本研究。在数字之间呈现（干扰性PASAT）和不呈现（PASAT）干扰性日语音节假名的情况下进行听觉连续加法测试（PASAT）。采用组块设计。受试者交替进行每项任务三次。
在两项任务中，健康对照者的表现均优于TBI患者。进行PASAT时，健康对照者除右侧前额叶皮质（PFC）外，每个感兴趣区域均表现出显著活动，但TBI患者仅在左侧前额叶前部和左侧PFC表现出显著活动。进行干扰性PASAT时，右侧PFC在健康对照者中活跃，但在TBI患者中不活跃。
这些结果证实，中重度TBI患者受到影响顺序处理的干扰因素的影响。提示TBI患者的工作记忆受到干扰性刺激的影响，而健康个体则不受影响。
