Mittal Medha, Jain Rahul, Talukdar Bibek, Kumar Manish, Kapoor Kapil
Chacha Nehru Bal Chikitsalya (Affiliated to Department of Pediatrics, Maulana Azad Medical College), Geeta Colony, Delhi, India.
J Vector Borne Dis. 2014 Jun;51(2):115-8.
BACKGROUND & OBJECTIVES: Vivax malaria has long been considered a benign entity. However, an increasing number of reports are highlighting that it may no longer be so. An investigation was carried out to study the profile of malarial admissions in a tertiary care pediatric hospital and to analyse the burden of vivax-related complications.
It is a retrospective observational study. The medical case records of all the patients admitted in the year 2011 with the clinical diagnosis of malaria and laboratory evidence in the form of positive peripheral smear and/or rapid malarial antigen test were retrieved and retrospectively analysed.
Overall, 198 cases were included, 128 (64.6%) were due to Plasmodium vivax, 66 (33.3%) due to P. falciparum and 4 (2%) had evidence of mixed infection of Pv + Pf. The clinical features on admission were similar in all the groups. In total, 64/128 (50%) patients with vivax infection had one or more complications with severe anemia in 33 (26%) and cerebral malaria in 16 (12.5%). Six deaths were reported in P. vivax cases. In the falciparum group, 52 (78.8%) had one or more complications with severe anemia in 37 (56.1%) and cerebral malaria in 24 (36.4%). Four deaths were reported in P. falciparum cases.
INTERPRETATION & CONCLUSION: Overall because of their larger numbers, vivax patients outnumbered other groups, with regards to severe complications and deaths. It was concluded that vivax malaria is emerging as an important cause of malaria-related complications in children.
间日疟长期以来一直被认为是一种良性疾病。然而，越来越多的报告表明情况可能并非如此。开展了一项调查，以研究一家三级护理儿科医院疟疾住院患者的情况，并分析间日疟相关并发症的负担。
这是一项回顾性观察研究。检索了2011年所有临床诊断为疟疾且有外周血涂片阳性和/或快速疟原虫抗原检测等实验室证据的患者的病历，并进行回顾性分析。
总体纳入198例病例，其中128例（64.6%）由间日疟原虫引起，66例（33.3%）由恶性疟原虫引起，4例（2%）有间日疟原虫和恶性疟原虫混合感染的证据。所有组入院时的临床特征相似。间日疟感染患者中共有64/128例（50%）出现一种或多种并发症，其中33例（26%）为严重贫血，16例（12.5%）为脑型疟疾。间日疟病例报告有6例死亡。在恶性疟组中，52例（78.8%）出现一种或多种并发症，其中37例（56.1%）为严重贫血，24例（36.4%）为脑型疟疾。恶性疟病例报告有4例死亡。
总体而言，由于间日疟患者数量较多，在严重并发症和死亡方面，间日疟患者比其他组更多。得出的结论是，间日疟正在成为儿童疟疾相关并发症的一个重要原因。
