循环 GDF15、MMP7 和 miR-200c 水平作为胃癌的不良预后标志物。
Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer.
机构信息
Translational Cancer Research Department, La Coruña Biomedical Research Institute (INIBIC), Carretera del Pasaje s/n, 15006 La Coruña, Spain.
出版信息
Future Oncol. 2014 May;10(7):1187-202. doi: 10.2217/fon.13.263.
AIM
To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed.
PATIENTS & METHODS: Fifty-two GC and 23 control samples were included.
RESULTS
GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033).
CONCLUSION
GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.
目的
分析 GDF15 和 MMP7 血清水平作为胃癌（GC）患者的诊断生物标志物。还分析了 GDF15 和 MMP7 血清水平与 miR-200c 血液表达联合的预后价值。
患者和方法
纳入 52 例 GC 和 23 例对照样本。
结果
GDF15 和 MMP7 被证明是 GC 诊断的有力工具。在单因素分析中，GDF15 和 MMP7 水平升高与无进展生存期和总生存期缩短相关。在多因素分析中，高水平的 GDF15、MMP7 和 miR-200c 的组合是死亡的独立预测因子（p = 0.033）。
结论
GDF15 和 MMP7 血清水平对 GC 具有诊断价值。由 GDF15、MMP7 和 miR-200c 形成的组合标志物预示 GC 患者的不良演变。
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