Translational Cancer Research Department, La Coruña Biomedical Research Institute (INIBIC), Carretera del Pasaje s/n, 15006 La Coruña, Spain.
Future Oncol. 2014 May;10(7):1187-202. doi: 10.2217/fon.13.263.
To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed.
PATIENTS & METHODS: Fifty-two GC and 23 control samples were included.
GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033).
GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.
分析 GDF15 和 MMP7 血清水平作为胃癌（GC）患者的诊断生物标志物。还分析了 GDF15 和 MMP7 血清水平与 miR-200c 血液表达联合的预后价值。
纳入 52 例 GC 和 23 例对照样本。
GDF15 和 MMP7 被证明是 GC 诊断的有力工具。在单因素分析中，GDF15 和 MMP7 水平升高与无进展生存期和总生存期缩短相关。在多因素分析中，高水平的 GDF15、MMP7 和 miR-200c 的组合是死亡的独立预测因子（p = 0.033）。
GDF15 和 MMP7 血清水平对 GC 具有诊断价值。由 GDF15、MMP7 和 miR-200c 形成的组合标志物预示 GC 患者的不良演变。
