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miR-200c 在胃癌中的诊断和预后价值：一项荟萃分析。

The Diagnostic and Prognostic Value of miR-200c in Gastric Cancer: A Meta-Analysis.

机构信息

Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

出版信息

Dis Markers. 2019 Apr 4;2019:8949618. doi: 10.1155/2019/8949618. eCollection 2019.

DOI:10.1155/2019/8949618
PMID:31089400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6476052/
Abstract

BACKGROUND

The role of miR-200c in gastric cancer remains controversial. This study is aimed at clarifying the diagnostic and prognostic value of miR-200c in gastric cancer through a meta-analysis.

METHODS

A comprehensive literature search of PubMed, Embase, and Ovid library databases was conducted. The studies included were those conducted before December 2017. The sensitivity and specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under curve (AUC) were used to estimate the diagnostic value of miR-200c. Meanwhile, the pooled hazard ratio (HR) was used to estimate the prognostic value of miR-200c.

RESULTS

For the diagnostic value of miR-200c, six studies that included 202 patients with gastric cancer and 250 normal controls were analyzed. The sensitivity, specificity, PLR, NLR, DOR, and AUC were 0.74, 0.66, 2.20, 0.40, 5.34, and 0.75, respectively. Subgroup analysis showed no significant difference in the type of the sample, method for testing miR-200c, and ethnicity among the patients. Meanwhile, for the prognostic value of miR-200c, seven studies comprising 935 patients with gastric cancer were analyzed. The pooled results showed that miR-200c expression was associated with overall survival (HR = 2.19) and disease-free survival (HR = 1.73), but not with progression-free survival (HR = 1.64) in patients with gastric cancer. There was no publication bias across the studies.

CONCLUSIONS

Both serum and tissue miR-200c have moderate diagnostic accuracy in gastric cancer. miR-200c could also be used as a valuable indicator for predicting the prognosis of gastric cancer patients.

摘要

背景

miR-200c 在胃癌中的作用仍存在争议。本研究旨在通过荟萃分析阐明 miR-200c 在胃癌中的诊断和预后价值。

方法

对 PubMed、Embase 和 Ovid 图书馆数据库进行全面的文献检索。纳入的研究为截至 2017 年 12 月前开展的研究。采用敏感度、特异度、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）和曲线下面积（AUC）评估 miR-200c 的诊断价值。同时，采用合并风险比（HR）评估 miR-200c 的预后价值。

结果

对于 miR-200c 的诊断价值，分析了 6 项包含 202 例胃癌患者和 250 例正常对照的研究。敏感度、特异度、PLR、NLR、DOR 和 AUC 分别为 0.74、0.66、2.20、0.40、5.34 和 0.75。亚组分析显示，患者的样本类型、检测 miR-200c 的方法和种族间无明显差异。同时，对于 miR-200c 的预后价值，分析了 7 项包含 935 例胃癌患者的研究。合并结果显示，miR-200c 的表达与胃癌患者的总生存（HR=2.19）和无病生存（HR=1.73）相关，但与无进展生存（HR=1.64）无关。各研究间无发表偏倚。

结论

血清和组织 miR-200c 对胃癌均具有中等诊断准确性。miR-200c 也可作为预测胃癌患者预后的有价值指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/66e01006d04d/DM2019-8949618.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/43508db9dd00/DM2019-8949618.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/a4c8c5164dcd/DM2019-8949618.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/66e01006d04d/DM2019-8949618.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/43508db9dd00/DM2019-8949618.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/3365ba0207a4/DM2019-8949618.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/84855f91bd6f/DM2019-8949618.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/f2628cc7beb2/DM2019-8949618.004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/a4c8c5164dcd/DM2019-8949618.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/6476052/66e01006d04d/DM2019-8949618.007.jpg

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