酪氨酸硝化作为细胞死亡的介质。
Tyrosine nitration as mediator of cell death.
作者信息
Franco María C, Estévez Alvaro G
机构信息
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA.
出版信息
Cell Mol Life Sci. 2014 Oct;71(20):3939-50. doi: 10.1007/s00018-014-1662-8. Epub 2014 Jun 20.
Abstract
Nitrotyrosine is used as a marker for the production of peroxynitrite and other reactive nitrogen species. For over 20 years the presence of nitrotyrosine was associated with cell death in multiple pathologies. Filling the gap between correlation and causality has proven to be a difficult task. Here, we discuss the evidence supporting tyrosine nitration as a specific posttranslational modification participating in the induction of cell death signaling pathways.
摘要
硝基酪氨酸被用作过氧亚硝酸盐和其他活性氮物质生成的标志物。二十多年来，硝基酪氨酸的存在与多种病理状态下的细胞死亡相关。事实证明，填补相关性与因果关系之间的空白是一项艰巨的任务。在此，我们讨论支持酪氨酸硝化作为一种参与细胞死亡信号通路诱导的特定翻译后修饰的证据。
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