Department of Biomedical Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Department of Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Drug Discov Today. 2014 Nov;19(11):1769-1774. doi: 10.1016/j.drudis.2014.06.008. Epub 2014 Jun 16.
Calcitriol, the hormonally active form of vitamin D, is well known for its diverse pharmacological activities, including modulation of cell growth, neuromuscular and immune function and reduction of inflammation. Calcitriol and its analogs exert potent effects on cellular differentiation and proliferation, regulate apoptosis and produce immunomodulatory effects. The purpose of this review is to provide information on various physiological and pharmacological activities of calcitriol and its newly discovered analogs. Special emphasis is given to skin diseases, cancer, diabetes and multiple sclerosis. A discussion is raised on the mechanisms of action of calcitriol and its analogs in various diseases, as well as on possible methods of delivery and targeting.
骨化三醇，维生素 D 的活性形式，以其多种药理学活性而闻名，包括调节细胞生长、神经肌肉和免疫功能以及减少炎症。骨化三醇及其类似物对细胞分化和增殖具有强大的作用，调节细胞凋亡并产生免疫调节作用。本综述的目的是提供关于骨化三醇及其新发现的类似物的各种生理和药理学活性的信息。特别强调了骨化三醇及其类似物在皮肤病、癌症、糖尿病和多发性硬化症中的应用。讨论了骨化三醇及其类似物在各种疾病中的作用机制，以及可能的传递和靶向方法。
