25-羟维生素 D 作为斑块状银屑病和其他皮肤病维生素 D 状态的生物标志物：一项横断面研究。

25-Hydroxyvitamin D as a biomarker of vitamin D status in plaque psoriasis and other dermatological diseases: a cross-sectional study.

机构信息

MD, MSc, PhD. Researcher, Physician and Professor, Núcleo de Pesquisa em Dermatologia (NUPEDE), Faculty of Medicine, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora (MG), Brazil; and Researcher, Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Faculty of Pharmacy, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora (MG), Brazil.

MD, MSc, PhD. Physician and Professor, Núcleo de Pesquisa em Dermatologia (NUPEDE), Faculty of Medicine, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora (MG), Brazil.

出版信息

Sao Paulo Med J. 2022 Aug 12;141(2):131-137. doi: 10.1590/1516-3180.2022.0164.R1.19052022. eCollection 2022.

DOI:10.1590/1516-3180.2022.0164.R1.19052022

PMID:35976371

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10005464/

Abstract

BACKGROUND

Hypovitaminosis D is a public health problem associated with several chronic inflammatory and immunological diseases, including psoriasis.

OBJECTIVES

This study aimed to determine the prevalence of hypovitaminosis D in patients with plaque psoriasis. A comparison was made between vitamin D levels in patients with psoriasis and those with other non-inflammatory dermatoses without photosensitivity. In addition, it evaluated the effects of the patients' Fitzpatrick skin phototype and the season of the year on the serum levels of vitamin D.

DESIGN AND SETTINGS

A retrospective cross-sectional study was conducted at an outpatient clinic in a university center in Juiz de Fora (MG), Brazil.

METHODS

A review of dermatology patients' demographic data, including skin phototype and serum levels of 25-hydroxyvitamin D [25(OH)D], over 12 months in 2016.

RESULTS

This study included 554 patients: 300 patients allocated to the plaque psoriasis group and 254 control patients with other dermatological diseases. Regarding the season of the year, 229, 132, 62, and 131 participants were evaluated in summer, autumn, winter, and spring, respectively. As for the skin phototype, 397, 139, and 18 patients had phototypes III, IV, and V, respectively. The serum levels of 25(OH)D were significantly lower in the psoriasis group (24.91 ± 7.16 ng/mL) than in the control group (30.37 ± 8.14 ng/mL).

CONCLUSIONS

Hypovitaminosis D (< 30 ng/mL) was present in 76.66% of patients with psoriasis versus 53.94% of control patients. Vitamin D deficiency (< 20 ng/mL) was observed in 25% of the patients with psoriasis versus 8.66% in the control group (P < 0.001). The season and patient's skin phototype were independent predictors of serum vitamin D levels.

摘要

背景

维生素 D 缺乏是与包括银屑病在内的几种慢性炎症性和免疫性疾病相关的公共健康问题。

目的

本研究旨在确定斑块型银屑病患者中维生素 D 缺乏的患病率。比较了银屑病患者和非炎症性皮肤病且无光敏性患者的维生素 D 水平。此外，还评估了患者的 Fitzpatrick 皮肤光型和一年中季节对血清维生素 D 水平的影响。

设计和设置

这是一项在巴西茹伊斯-迪福拉（Juiz de Fora）的大学中心的门诊进行的回顾性横断面研究。

方法

回顾了 2016 年 12 个月中皮肤科患者的人口统计学数据，包括皮肤光型和 25-羟维生素 D [25(OH)D]的血清水平。

结果

这项研究共纳入 554 例患者：300 例患者被分配到斑块型银屑病组，254 例对照患者患有其他皮肤病。按季节划分，分别有 229、132、62 和 131 例患者在夏季、秋季、冬季和春季接受评估。就皮肤光型而言，分别有 397、139 和 18 例患者为光型 III、IV 和 V。银屑病组的血清 25(OH)D 水平明显低于对照组（24.91 ± 7.16 ng/mL 比 30.37 ± 8.14 ng/mL）。