Chun Ho Jong, Lee Hae Giu, Lyoo Won Seok, Lee Ji Youl, Kim Jina
Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
School of Textiles, Yeungnam University, Gyeongsan, Republic of Korea.
Biomed Mater Eng. 2014;24(4):1743-50. doi: 10.3233/BME-140986.
Syndiotactic polyvinyl alcohol (PVA) had been developed to overcome the drawbacks of atactic PVA spheres that deform easily, which can lead to non-target embolization. This study was performed to evaluate the in vivo stability of spherical shape of the syndiotactic PVA spheres. Selective arteriography and transarterial embolization (TAE) were performed in the main renal arteries of eight New Zealand white rabbits using syndiotactic PVA sphere that consisted of syndiotactic PVA skin and a copolymer core of vinyl acetate/vinyl pivalate. The size of the syndiotactic PVA spheres used for the TAE was 212-355 μm. The rabbits were sacrificed 12-14 days after TAE. Gross and microscopic examinations of each kidney were performed. The microscopic examination showed infarction of all embolized kidneys. Syndiotactic PVA spheres were seen uniformly within the arterial lumen and appeared as round ring-like structures without any deformity. The syndiotactic PVA spheres exclusively occupied the arterial lumen. As a conclusion, syndiotactic PVA spheres maintained their spherical shape without significant deformation in this in vivo short-term experimental study. Further investigation is necessary for evaluation of detailed effects of physical stability in tumor embolization.
间规聚醋酸乙烯酯（PVA）已被开发出来，以克服无规PVA球体容易变形的缺点，这种变形可能导致非靶向栓塞。本研究旨在评估间规PVA球体在体内的球形稳定性。使用由间规PVA外壳和醋酸乙烯酯/新戊酸乙烯酯共聚物核心组成的间规PVA球体，对8只新西兰白兔的主肾动脉进行选择性动脉造影和经动脉栓塞术（TAE）。用于TAE的间规PVA球体大小为212 - 355μm。TAE术后12 - 14天处死兔子。对每个肾脏进行大体和显微镜检查。显微镜检查显示所有栓塞肾脏均有梗死。间规PVA球体均匀地见于动脉腔内，呈圆形环状结构，无任何变形。间规PVA球体完全占据动脉腔。总之，在这项体内短期实验研究中，间规PVA球体保持其球形，无明显变形。对于评估物理稳定性在肿瘤栓塞中的详细作用，还需要进一步研究。
