Li Wei, Yang Jun, Gu Chengtao, Yin Yu, Li Zhi, Ni Caifang
Department of Vascular and Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
J Cancer Res Ther. 2020;16(2):276-279. doi: 10.4103/jcrt.JCRT_435_19.
To study the arterial distribution of embosphere microsphere (EM) and polyvinyl alcohol (PVA) particles in rabbit mesenteric artery using in vivo microscopy.To study the arterial distribution of embosphere microsphere (EM) and polyvinyl alcohol (PVA) particles in rabbit mesenteric artery using in vivo microscopy.
Sixteen New Zealand rabbits were divided into four groups, namely large PVA (560-710 μm), small PVA (150-350 μm), large EM (500-700 μm), and small EM (100-300 μm). The mesenteric arteries of the experimental animals were embolized under fluoroscopic guidance and visualized using in vivo microscopy. The embolized vessel diameter and arterial distribution of embolic agents were compared.
The diameters of occluded vessels in large PVA, small PVA, large EM, and small EM groups were 430.60 ± 67.30, 200.95 ± 70.54, 387.79 ± 92.51, and 143.81 ± 39.65 μm, respectively. PVA occluded significantly larger vessels than EM when the particle size was similar (P < 0.001). The proportion of EM at the bifurcation of the artery was significantly higher than that of PVA particles (large PVA < large EM, χ = 4.325, P < 0.038; small PVA < small EM, χ = 6.68, P < 0.01).
Both PVA and EM could occlude vessels smaller than the particle size, and EM resulted in deeper penetration. The location of embolic particles in the artery is mainly related to the shape of particles.
采用体内显微镜技术研究兔肠系膜动脉中栓塞微球(EM)和聚乙烯醇(PVA)颗粒的动脉分布情况。采用体内显微镜技术研究兔肠系膜动脉中栓塞微球(EM)和聚乙烯醇(PVA)颗粒的动脉分布情况。
将16只新西兰兔分为四组,即大颗粒PVA(560 - 710μm)、小颗粒PVA(150 - 350μm)、大颗粒EM(500 - 700μm)和小颗粒EM(100 - 300μm)。在荧光透视引导下对实验动物的肠系膜动脉进行栓塞,并使用体内显微镜进行观察。比较栓塞剂的栓塞血管直径和动脉分布情况。
大颗粒PVA组、小颗粒PVA组、大颗粒EM组和小颗粒EM组中闭塞血管的直径分别为430.60±67.30、200.95±70.54、387.79±92.51和143.81±39.65μm。当颗粒大小相似时,PVA闭塞的血管明显大于EM(P < 0.001)。动脉分叉处EM的比例明显高于PVA颗粒(大颗粒PVA < 大颗粒EM,χ = 4.325,P < 0.038;小颗粒PVA < 小颗粒EM,χ = 6.68,P < 0.01)。
PVA和EM均可闭塞小于颗粒大小的血管,且EM导致的穿透更深。栓塞颗粒在动脉中的位置主要与颗粒形状有关。