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使用 CD26 区分 CML LSCs 与 HSCs。

Distinguishing CML LSCs from HSCs using CD26.

机构信息

British Columbia Cancer Agency; University of British Columbia.

出版信息

Blood. 2014 Jun 19;123(25):3851-2. doi: 10.1182/blood-2014-05-574293.

DOI:10.1182/blood-2014-05-574293
PMID:24948622
Abstract

In this issue of Blood, Herrmann et al elegantly demonstrate that CD26 is a new, specific chronic myeloid leukemia (CML) stem cell biomarker that phenotypically distinguishes leukemic stem cells (LSCs) from normal hematopoietic stem cells (HSCs), and that it is a potential therapeutic target in CML.

摘要

在本期《Blood》中,Herrmann 等人精彩地证明了 CD26 是一种新的、特异性的慢性髓系白血病(CML)干细胞标志物,它在表型上可区分白血病干细胞(LSCs)和正常造血干细胞(HSCs),并且是 CML 的一个潜在治疗靶点。

相似文献

1
Distinguishing CML LSCs from HSCs using CD26.使用 CD26 区分 CML LSCs 与 HSCs。
Blood. 2014 Jun 19;123(25):3851-2. doi: 10.1182/blood-2014-05-574293.
2
Flow Cytometry Assessment of CD26 Leukemic Stem Cells in Peripheral Blood: A Simple and Rapid New Diagnostic Tool for Chronic Myeloid Leukemia.流式细胞术检测外周血 CD26 白血病干细胞:慢性髓性白血病的一种简单、快速的新型诊断工具。
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Oncotarget. 2016 May 31;7(22):33016-24. doi: 10.18632/oncotarget.9108.
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Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.骨髓龛中小分子 RNA-126 的转移调控慢性髓系白血病中白血病干细胞的自我更新。
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CD26 expression on circulating CD34+/CD38- progenitor population is a specific and reliable tool for the rapid flow cytometric diagnosis of chronic myeloid leukemia-A single-center validation study.循环 CD34+/CD38-祖细胞群上的 CD26 表达是一种快速流式细胞术诊断慢性髓性白血病的特异性和可靠工具-单中心验证研究。
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Expression of CD25 on leukemic stem cells in BCR-ABL1 CML: Potential diagnostic value and functional implications.BCR-ABL1 慢性粒细胞白血病中白血病干细胞上 CD25 的表达:潜在诊断价值及功能意义
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引用本文的文献

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Properties of Leukemic Stem Cells in Regulating Drug Resistance in Acute and Chronic Myeloid Leukemias.白血病干细胞在调控急性和慢性髓系白血病耐药性中的特性
Biomedicines. 2022 Jul 30;10(8):1841. doi: 10.3390/biomedicines10081841.
2
Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia.外周血CD26阳性白血病干细胞作为慢性髓性白血病可能的诊断和预后标志物
Leuk Res Rep. 2022 May 9;17:100321. doi: 10.1016/j.lrr.2022.100321. eCollection 2022.
3
Validating Cell Surface Proteases as Drug Targets for Cancer Therapy: What Do We Know, and Where Do We Go?
验证细胞表面蛋白酶作为癌症治疗的药物靶点:我们知道什么,又将何去何从?
Cancers (Basel). 2022 Jan 26;14(3):624. doi: 10.3390/cancers14030624.
4
In Vitro Comparison of the Effects of Imatinib and Ponatinib on Chronic Myeloid Leukemia Progenitor/Stem Cell Features.体外比较伊马替尼和帕纳替尼对慢性髓性白血病祖细胞/干细胞特征的影响。
Target Oncol. 2020 Oct;15(5):659-671. doi: 10.1007/s11523-020-00741-x.
5
Residual Peripheral Blood CD26 Leukemic Stem Cells in Chronic Myeloid Leukemia Patients During TKI Therapy and During Treatment-Free Remission.慢性髓性白血病患者在酪氨酸激酶抑制剂治疗期间及无治疗缓解期的残留外周血CD26白血病干细胞
Front Oncol. 2018 May 30;8:194. doi: 10.3389/fonc.2018.00194. eCollection 2018.