Colvin J R, Kenny G N
University Department of Anaesthesia, Glasgow Royal Infirmary.
Anaesthesia. 1989 Jan;44(1):37-41. doi: 10.1111/j.1365-2044.1989.tb11096.x.
Arterial hypertension after cardiac surgery is common and is associated with increased morbidity. Glyceryl trinitrate may be a more suitable agent for control of hypertension than sodium nitroprusside. We have developed a closed-loop system for the Atari 1040ST microcomputer to control arterial pressure by the simultaneous infusion of two vasodilators under computer control. Use of this system with glyceryl trinitrate and sodium nitroprusside in 24 patients who required vasodilators after cardiopulmonary bypass, revealed that hypertension was controlled by glyceryl trinitrate alone in 14 of the patients and 10 required supplementary sodium nitroprusside. The results suggest that glyceryl trinitrate is a suitable agent for control of hypertension after cardiac surgery in the majority of patients. They also show that a sizeable minority required additional sodium nitroprusside, and that an automated 'dual pump' system is a satisfactory method of administering two vasodilators in this way.
心脏手术后的动脉高血压很常见，且与发病率增加相关。与硝普钠相比，硝酸甘油可能是控制高血压更合适的药物。我们为雅达利1040ST微型计算机开发了一种闭环系统，通过在计算机控制下同时输注两种血管扩张剂来控制动脉血压。在24例体外循环后需要血管扩张剂的患者中使用该系统联合硝酸甘油和硝普钠，结果显示14例患者仅用硝酸甘油就能控制高血压，10例患者需要补充硝普钠。结果表明，硝酸甘油是大多数心脏手术后控制高血压的合适药物。研究结果还表明，相当一部分少数患者需要额外使用硝普钠，并且自动“双泵”系统是以此方式给药两种血管扩张剂的一种令人满意的方法。
