de Asla R A, Benis A M, Jurado R A, Litwak R S
J Thorac Cardiovasc Surg. 1985 Jan;89(1):115-20.
Manual administration of sodium nitroprusside in patients who have undergone cardiac operations can be associated with wide swings in mean systemic arterial pressure. Moreover, it is necessary for constant attention to be paid in order to minimize these potentially catastrophic arterial pressure changes. A microcomputer-based controller was constructed in the belief that it might improve the accuracy of systemic arterial pressure control as well as relieve the clinical staff of a time-consuming task. Comparison was made of the effectiveness of manual control versus computer control of sodium nitroprusside infusion in two groups of patients with similar clinical characteristics. In the manual control group the mean systemic arterial pressure could be maintained within 5 mm Hg of the target pressure only half (52%) of the time. In the computer-controlled group the mean systemic arterial pressure was maintained within 5 mm Hg of the target pressure 94% of the time (p less than 0.005). Thus, computerized control of sodium nitroprusside infusion eliminated the need for an intensive care unit nurse to be "locked into" the task of making frequent adjustments of infusion rate. Of even greater importance, control of mean systemic arterial pressure was more precise.
在接受心脏手术的患者中手动给予硝普钠可能会导致平均体循环动脉压大幅波动。此外，必须持续密切关注，以尽量减少这些可能具有灾难性的动脉压变化。基于这样的信念构建了一个微机控制器，即它可能提高体循环动脉压控制的准确性，并使临床工作人员从一项耗时的任务中解脱出来。对两组临床特征相似的患者在硝普钠输注的手动控制与计算机控制的有效性方面进行了比较。在手动控制组中，平均体循环动脉压仅在一半（52%）的时间内能够维持在目标压力的5毫米汞柱范围内。在计算机控制组中，平均体循环动脉压在94%的时间内维持在目标压力的5毫米汞柱范围内（p小于0.005）。因此，硝普钠输注的计算机化控制消除了重症监护病房护士“专注于”频繁调整输注速率这项任务的必要性。更重要的是，平均体循环动脉压的控制更加精确。
