Campkin T V, Flinn R M
Department of Anaesthetics, Queen Elizabeth Hospital, Birmingham.
Anaesthesia. 1989 Jan;44(1):50-4. doi: 10.1111/j.1365-2044.1989.tb11099.x.
The effect of isoflurane 1.0% and 1.5% with nitrous oxide on ventricular cerebrospinal fluid pressure was studied in 17 patients who underwent intracranial shunt procedures. Isoflurane at both concentrations caused significant increases in cerebrospinal fluid pressure during normocapnic ventilation, but these could be prevented by simultaneous hyperventilation or by the prior induction of hypocapnia. Decreases in mean arterial pressure occurred also, and resulted in a significant reduction in cerebral perfusion pressure in normocapnic patients.
在17例接受颅内分流手术的患者中，研究了1.0%和1.5%异氟烷与氧化亚氮对脑室脑脊液压力的影响。在正常碳酸血症通气期间，两种浓度的异氟烷均导致脑脊液压力显著升高，但可通过同时进行过度通气或预先诱发低碳酸血症来预防。平均动脉压也出现下降，并导致正常碳酸血症患者的脑灌注压显著降低。
