Gómez Sainz J J, Eléxpuru Camiruaga J A, Fernández Cano F, de la Herrán J L
Servicio de Anestesia y Reanimación, Santo Hospital Civil, Bilbão, Spain.
Br J Anaesth. 1988 Sep;61(3):347-9. doi: 10.1093/bja/61.3.347.
The effect of isoflurane on intraventricular pressure (IVP) was examined during nitrous oxide with fentanyl anaesthesia in patients undergoing craniotomy during normocapnia or hypocapnia. Hypocapnic patients (n = 30, PaCO2 3.3 (0.1) kPa) were allocated to three groups (A, B, C; n = 10 each) according to the inspired concentration of isoflurane (1%, 1.5%, 2%). Normocapnic patients (n = 10, PaCO2 4.7 (0.1) kPa) received an inspired concentration of 1% isoflurane (group D). In patients in groups C and D, IVP increased significantly in response to isoflurane (P less than 0.01). In groups A and B, IVP did not change significantly (P greater than 0.05). Mean arterial pressure and cerebral perfusion pressure decreased significantly (P less than 0.001) in all groups in response to isoflurane.
在正压通气或低压通气期间，对接受开颅手术的患者，在氧化亚氮复合芬太尼麻醉下，研究了异氟烷对脑室内压（IVP）的影响。将低压通气患者（n = 30，动脉血二氧化碳分压[PaCO2] 3.3 [0.1] kPa）根据异氟烷吸入浓度（1%、1.5%、2%）分为三组（A、B、C组；每组n = 10）。正压通气患者（n = 10，PaCO2 4.7 [0.1] kPa）吸入1%异氟烷（D组）。C组和D组患者吸入异氟烷后脑室内压显著升高（P < 0.01）。A组和B组脑室内压无显著变化（P > 0.05）。所有组吸入异氟烷后平均动脉压和脑灌注压均显著降低（P < 0.001）。
