Ashtari Fereshteh, Rezvani Roya, Afshar Hamid
Department of Neurology, Isfahan University of Medical Sciences, Ayatolah Kashani Hospital, Medical Faculty, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Psychiatric, Isfahan University of Medical Sciences, Ayatolah Kashani Hospital, Medical Faculty, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2014 Mar;19(3):228-33.
Sexual dysfunction (SD) is a common reported problem in patients with multiple sclerosis (MS).
to examine frequency and distribution of SD dimensions and to determine whether SD is related to various clinical and demographic variables in female patients.
A total of 271 MS women (age: 19-50 years) participated in this cross-sectional study. We used a structured demographic and clinical interview and Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19). Disability was rated by Expanded Disability Status Score (EDSS).
63.5% (n = 173) of women had SD included 142 (52.4%) women with primary SD, 102 (37.5%) women with secondary SD and 120 (41%) women with tertiary SD. The most common SD-related complaint was orgasmic problem (41.2%). Women with primary SD were significantly older and had higher EDSS score. No significant relationship was found between primary SD and disease duration. Fatigue (OR = 2.69, 95% CI: 1.352-5.385, P = 0.005), memory and concentration complaints (OR = 1.915, 95% CI: 1.034-3.546, P = 0.039) and some of urinary symptoms such as frequency (OR = 2.108, 95% CI: 1.015-4.375, P = 0.045) were seem to be the significant predictors. Fatigue was also found to be the most powerful predicting factor for tertiary SD (OR = 2.793, 95% CI: 1.358-5.744 P = 0.005).
SD, a common multifactorial problem among MS women, can arise at any time during the disease and with any level of disability. However, we found relationships between SD and some of clinical variables and symptoms. Understanding these relationships would help us to develop practical approach and treatment for SD.
性功能障碍（SD）是多发性硬化症（MS）患者中常见的报告问题。
研究性功能障碍维度的频率和分布，并确定女性患者的性功能障碍是否与各种临床和人口统计学变量相关。
共有271名MS女性（年龄：19 - 50岁）参与了这项横断面研究。我们采用了结构化的人口统计学和临床访谈以及多发性硬化症亲密关系和性问卷 - 19（MSISQ - 19）。残疾程度通过扩展残疾状态评分（EDSS）进行评定。
63.5%（n = 173）的女性存在性功能障碍，其中142名（52.4%）女性为原发性性功能障碍，102名（37.5%）女性为继发性性功能障碍，120名（41%）女性为三发性性功能障碍。最常见的与性功能障碍相关的主诉是性高潮问题（41.2%）。原发性性功能障碍的女性年龄显著更大，EDSS评分更高。原发性性功能障碍与疾病持续时间之间未发现显著关系。疲劳（OR = 2.69，95% CI：1.352 - 5.385，P = 0.005）、记忆和注意力问题（OR = 1.915，95% CI：1.034 - 3.546，P = 0.039）以及一些泌尿系统症状如尿频（OR = 2.108，95% CI：1.015 - 4.375，P = 0.045）似乎是显著的预测因素。疲劳也是三发性性功能障碍最有力的预测因素（OR = 2.793，95% CI：1.358 - 5.744，P = 0.005）。
性功能障碍是MS女性中常见的多因素问题，可在疾病的任何阶段以及任何残疾程度下出现。然而，我们发现了性功能障碍与一些临床变量和症状之间的关系。了解这些关系将有助于我们制定针对性功能障碍的实用方法和治疗方案。
