Sabanagic-Hajric Selma, Memic-Serdarevic Amra, Sulejmanpasic Gorana, Mehmedika-Suljic Enra
Department of Neurology, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Department of Psychiatry, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Mater Sociomed. 2022 Sep;34(3):188-192. doi: 10.5455/msm.2022.34.188-192.
Multiple sclerosis is a progressive inflammatory disease of the the central nervous system. Problems with sexual functions are the common features of multiple sclerosis and important factor that contribute to the quality of life among affected persons.
The aim of the study was to evaluate the influence of sociodemographic and clinical characteristics on sexual functions domains of health related quality of life (HRQOL) in multiple sclerosis patients.
This study included 100 MS patients treated at the Department of Neurology, Clinical Center University of Sarajevo. Inclusion criteria were an Expanded Disability Status Scale score between 1.0 and 6.5, age between 18 and 65 years, stable disease on enrollment. HRQOL was evaluated by the Multiple Sclerosis Quality of Life-54 questionnaire. Mann-Whitney and Kruskal-Wallis test were used for comparisons between sociodemographic and clinical characteristics and HRQOL scores.
Out of 60% of patients reported to have sexual dysfunction, and 55 % were female patients. Younger patients had statistical significant higher median value of sexual function score (91.68 vs. 58,28, p=0.001) and satisfaction with sexual life scores (62.5 vs 37.5 , p =0.019) comparing to older patients. Employed patients also showed statistical significant higher median value of sexual function score (82 vs. 66.7, p=0.003) comparing to unemployed patients and also statisticaly significant higher median scores considering satisfaction with sexual life among employed patients (p=0,001). There were no differences in sexual functions scores considering gender, marital status and education. Patients with higher level of disabilty, progressive type of disease, more relapses and longer diseas duration had statistical significant lower median value of sexual function score and also satifaction with sexual life scores, except for disease duration.
Aging, dysability and progression are major factors that contribute to lower sexual function scores and satisfaction with sexual life among multiple sclerosis patients. Althoug women reported sexual problems more often then men, impact of these problems on quality of life are similar in men and women with MS.
多发性硬化症是一种中枢神经系统的进行性炎症性疾病。性功能问题是多发性硬化症的常见特征，也是影响患者生活质量的重要因素。
本研究旨在评估社会人口统计学和临床特征对多发性硬化症患者健康相关生活质量（HRQOL）性功能领域的影响。
本研究纳入了萨拉热窝大学临床中心神经科治疗的100例多发性硬化症患者。纳入标准为扩展残疾状态量表评分在1.0至6.5之间，年龄在18至65岁之间，入组时病情稳定。采用多发性硬化症生活质量-54问卷评估HRQOL。采用Mann-Whitney和Kruskal-Wallis检验比较社会人口统计学和临床特征与HRQOL评分。
60%的患者报告有性功能障碍，其中55%为女性患者。与老年患者相比，年轻患者的性功能评分中位数（91.68对58.28，p=0.001）和性生活满意度评分中位数（62.5对37.5，p=0.019）在统计学上显著更高。与未就业患者相比，就业患者的性功能评分中位数（82对66.7，p=0.003）在统计学上也显著更高，并且就业患者在性生活满意度方面的中位数评分在统计学上也显著更高（p=0.001）。在性功能评分方面，性别、婚姻状况和教育程度没有差异。残疾程度较高、疾病为进展型、复发次数较多和病程较长的患者，除病程外，性功能评分中位数和性生活满意度评分在统计学上显著较低。
年龄、残疾和疾病进展是导致多发性硬化症患者性功能评分降低和性生活满意度降低的主要因素。尽管女性比男性更常报告性问题，但这些问题对多发性硬化症男性和女性生活质量的影响相似。
