Gastroenterology Department, University Hospital of Canary Islands, La Laguna, Tenerife, Spain.
Internal Medicine Department, Gastroenterology Unit, Alhossien Hospital, Alazhar University, Cairo, Egypt.
Endosc Ultrasound. 2012 Apr;1(1):17-22. doi: 10.7178/eus.01.004.
Accurate diagnosis and subtyping of lymphoma have important prognostic implications and are generally required for treatment planning. Histological assessment, immunophenotyping, and genetic studies are usually necessary. Endoscopic ultrasound guided-fine needle aspiration cytology (EUS-FNAC) is a minimally invasive technique widely used for the evaluation of deep-seated benign and malignant lesions. However, the value of cytological samples in lymphoma diagnosis is still a matter of debate. Endoscopic ultrasound guided-fine needle biopsy (EUS-FNAB) can provide tissue core samples that may help overcome the limitations of cytology. The aim of this review is to summarize the available literature regarding EUS-FNAC and EUS-FNAB for the diagnosis and subtyping of lymphoma. In addition, we discuss its usefulness in the management of primary extra-nodal lymphomas, as well as technical issues that may influence sample quality.
准确的诊断和淋巴瘤亚型分类具有重要的预后意义,通常也是治疗计划制定的必要条件。通常需要进行组织学评估、免疫表型分析和基因研究。内镜超声引导下细针抽吸细胞学检查(EUS-FNAC)是一种广泛用于评估深部良性和恶性病变的微创技术。然而,细胞学样本在淋巴瘤诊断中的价值仍存在争议。内镜超声引导下细针活检(EUS-FNAB)可以提供组织芯样本,这可能有助于克服细胞学的局限性。本综述的目的是总结关于 EUS-FNAC 和 EUS-FNAB 用于诊断和淋巴瘤亚型分类的现有文献。此外,我们还讨论了其在内脏外原发性结外淋巴瘤治疗管理中的作用,以及可能影响样本质量的技术问题。