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内镜超声引导下细针抽吸细胞学和活检在淋巴瘤评估中的应用。

Endoscopic ultrasound-guided fine needle aspiration cytology and biopsy in the evaluation of lymphoma.

机构信息

Gastroenterology Department, University Hospital of Canary Islands, La Laguna, Tenerife, Spain.

Internal Medicine Department, Gastroenterology Unit, Alhossien Hospital, Alazhar University, Cairo, Egypt.

出版信息

Endosc Ultrasound. 2012 Apr;1(1):17-22. doi: 10.7178/eus.01.004.

Abstract

Accurate diagnosis and subtyping of lymphoma have important prognostic implications and are generally required for treatment planning. Histological assessment, immunophenotyping, and genetic studies are usually necessary. Endoscopic ultrasound guided-fine needle aspiration cytology (EUS-FNAC) is a minimally invasive technique widely used for the evaluation of deep-seated benign and malignant lesions. However, the value of cytological samples in lymphoma diagnosis is still a matter of debate. Endoscopic ultrasound guided-fine needle biopsy (EUS-FNAB) can provide tissue core samples that may help overcome the limitations of cytology. The aim of this review is to summarize the available literature regarding EUS-FNAC and EUS-FNAB for the diagnosis and subtyping of lymphoma. In addition, we discuss its usefulness in the management of primary extra-nodal lymphomas, as well as technical issues that may influence sample quality.

摘要

准确的诊断和淋巴瘤亚型分类具有重要的预后意义,通常也是治疗计划制定的必要条件。通常需要进行组织学评估、免疫表型分析和基因研究。内镜超声引导下细针抽吸细胞学检查(EUS-FNAC)是一种广泛用于评估深部良性和恶性病变的微创技术。然而,细胞学样本在淋巴瘤诊断中的价值仍存在争议。内镜超声引导下细针活检(EUS-FNAB)可以提供组织芯样本,这可能有助于克服细胞学的局限性。本综述的目的是总结关于 EUS-FNAC 和 EUS-FNAB 用于诊断和淋巴瘤亚型分类的现有文献。此外,我们还讨论了其在内脏外原发性结外淋巴瘤治疗管理中的作用,以及可能影响样本质量的技术问题。

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