氧化应激生物标志物和抗氧化剂在阿尔茨海默病中的作用：一项系统综述
The roles of biomarkers of oxidative stress and antioxidant in Alzheimer's disease: a systematic review.
作者信息
Chang Ya-Ting, Chang Wen-Neng, Tsai Nai-Wen, Huang Chih-Cheng, Kung Chia-Te, Su Yu-Jih, Lin Wei-Che, Cheng Ben-Chung, Su Chih-Min, Chiang Yi-Fang, Lu Cheng-Hsien
机构信息
Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung 833, Taiwan ; Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung District, Kaohsiung 833, Taiwan.
出版信息
Biomed Res Int. 2014;2014:182303. doi: 10.1155/2014/182303. Epub 2014 May 14.
PURPOSE
Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies.
METHODS
PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD.
RESULTS AND CONCLUSION
Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.
目的
氧化应激在阿尔茨海默病（AD）的发病机制中起重要作用。本文旨在研究氧化应激生物标志物和抗氧化剂是否可作为AD的有用生物标志物，这可能构成未来临床研究的基础。
方法
系统检索PubMed、SCOPUS和科学网，以获取有关AD患者氧化应激标志物和抗氧化剂的现有数据的研究。
结果与结论
尽管大多数研究表明AD患者血清脂质过氧化标志物升高，但尚无充分证据证明将生物标志物常规用作AD严重程度或预后的预测指标是合理的。
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