循环内皮细胞与慢性肾脏病
Circulating endothelial cells and chronic kidney disease.
作者信息
Zhang Kunying, Yin Fang, Lin Lin
机构信息
Department of Nephrology, Weifang People's Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang, Shandong 261041, China.
出版信息
Biomed Res Int. 2014;2014:364738. doi: 10.1155/2014/364738. Epub 2014 May 18.
Abstract
Endothelial dysfunction may play a crucial role in initiation of the pathogenesis of vascular disease and atherosclerosis. The identification and quantification of circulating endothelial cells (CEC) have been developed as a novel marker of endothelial function. We describe, in great detail, mechanisms of endothelial dysfunction and CEC detachment. We also review the relationship between numbers of CEC and disease severity and response to treatment. In addition, we describe the possible clinical use of CEC in chronic kidney disease (CKD) and kidney transplantation. In summary, CEC have been developed as a novel approach to assess the endothelial damage. Measurement of the CEC level would provide an important diagnostic and prognostic value on the endothelium status and the long-term outcome of vascular dysfunction.
摘要
内皮功能障碍可能在血管疾病和动脉粥样硬化发病机制的起始过程中起关键作用。循环内皮细胞（CEC）的识别和定量已被开发为内皮功能的一种新型标志物。我们详细描述了内皮功能障碍和CEC脱离的机制。我们还综述了CEC数量与疾病严重程度及治疗反应之间的关系。此外，我们描述了CEC在慢性肾脏病（CKD）和肾移植中的可能临床应用。总之，CEC已被开发为一种评估内皮损伤的新方法。CEC水平的测量将为内皮状态和血管功能障碍的长期预后提供重要的诊断和预后价值。
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